Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26887359 | 0.89 | L3MBTL1 (0.49) | SIRT2NPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL24326051 | 0.81 | TDP1 (0.68) | SIRT2HTTSMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL26887361 | 0.81 | TDP1 (0.53) | SIRT2NPC1RAB9AHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL26691051 | 0.77 | LMNA (0.48) | SIRT2NPC1RAB9AHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29496319 | 0.77 | LMNA (0.48) | SIRT2NPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL7601476 | 0.76 | L3MBTL1 (0.61) | NPC1RAB9ASMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL26887830 | 0.76 | SIRT2 (0.47) | SIRT2L3MBTL1TDP1ATMLMNA | |
| SCHEMBL16242081 | 0.74 | NPC1 (0.63) | SIRT2NPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL1545132 | 0.74 | TDP1 (0.54) | SIRT2NPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL14848176 | 0.74 | SIRT2 (0.51) | SIRT2HTTL3MBTL1TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230373937-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2023-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230373937-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | SPNS2, SPCS2, SMN1; SMN2 | SIRT2 990/4885NPC1 504/4885RAB9A 4304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.