Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.66 |
| ▸ | IL1RN | P18510 | 1/20 | 0.66 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.66 |
| ▸ | HTR6 | P50406 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9001184 | 0.87 | KEAP1 (0.79) | KEAP1IL1RNERAP1HTR6ALDH1A1 | |
| SCHEMBL16900686 | 0.85 | CA12 (0.65) | HTR6ALDH1A1MEN1KMT2AITGA1 | |
| SCHEMBL15314389 | 0.81 | KMT2A (0.65) | KEAP1ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL31441925 | 0.81 | CA2 (0.68) | ALDH1A1MEN1KMT2AHPGDLMNA | |
| SCHEMBL25031372 | 0.80 | KEAP1 (1.00) | KEAP1IL1RNERAP1HTR6ALDH1A1 | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL114765 | 0.80 | KEAP1 (1.00) | KEAP1IL1RNERAP1HTR6ALDH1A1 | |
| SCHEMBL2692360 | 0.79 | KMT2A (0.74) | KEAP1IL1RNERAP1HTR6ALDH1A1 | |
| SCHEMBL1403148 | 0.79 | KMT2A (0.74) | KEAP1IL1RNERAP1ALDH1A1MEN1 | |
| SCHEMBL8081768 | 0.79 | KEAP1 (0.79) | KEAP1IL1RNERAP1HTR6ALDH1A1 | |
| SCHEMBL5730534 | 0.79 | IL1RN (0.66) | KEAP1IL1RNERAP1HTR6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796330-B2 | Inhibitors of histone deacetylase and prodrugs thereof | METHYLGENE INC. (CA) | 2014-08-05 | — | — | US | disclosed |
| US-8796330-B2 | Inhibitors of histone deacetylase and prodrugs thereof | METHYLGENE INC. (CA) | 2014-08-05 | — | — | US | disclosed |
| US-8796330-B2 | Inhibitors of histone deacetylase and prodrugs thereof | METHYLGENE INC. (CA) | 2014-08-05 | — | — | US | disclosed |
| US-20140024608-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | METHYLGENE INC. (CA) | 2014-01-23 | — | — | US | disclosed |
| US-20140024608-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | METHYLGENE INC. (CA) | 2014-01-23 | — | — | US | disclosed |
| US-20140024608-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | METHYLGENE INC. (CA) | 2014-01-23 | — | — | US | disclosed |
| EP-2573069-A2 | Inhibitors of histone deacetylase and prodrugs thereof | MethylGene Inc. (CA) | 2013-03-27 | — | — | EP | disclosed |
| EP-2573069-A2 | Inhibitors of histone deacetylase and prodrugs thereof | MethylGene Inc. (CA) | 2013-03-27 | — | — | EP | disclosed |
| US-RE43343-E1 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-05-01 | — | — | US | disclosed |
| US-RE43343-E1 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-05-01 | — | — | US | disclosed |
| US-20080146623-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | METHYLGENE INC. (CA) | 2008-06-19 | — | — | US | disclosed |
| US-RE39850-E1 | Aryl amide, -sulfonamide, or -urea derivatives; antiproliferative, antitumor, anticarcinogenic, and/or antimetastasis agents | METHYLGENE, INC. (CA) | 2007-09-18 | — | — | US | disclosed |
| EP-1748046-A2 | Inhibitors of histone deacetylase | Methylgene, Inc. (CA) | 2007-01-31 | — | — | EP | disclosed |
| US-20040266718-A1 | Inhibition of specific histone deacetylase isoforms | LI ZUOMEI (CA) | 2004-12-30 | — | — | US | disclosed |
| EP-1438404-A2 | INHIBITION OF SPECIFIC HISTONE DEACETYLASE ISOFORMS | Methylgene, Inc. (CA) | 2004-07-21 | — | — | EP | disclosed |
| US-6541661-B1 | For treating cell proliferative diseases and conditions | METHYLGENE, INC. (CA) | 2003-04-01 | — | — | US | disclosed |
| WO-2003006652-A2 | INHIBITION OF SPECIFIC HISTONE DEACETYLASE ISOFORMS | METHYLGENE, INC. (CA) | 2003-01-23 | — | — | WO | disclosed |
| EP-1233958-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2002-08-28 | — | — | EP | disclosed |
| US-20020061860-A1 | Antisense oligonucleotide inhibition of specific histone deacetylase isoforms | METHYLGENE, INC. (CA) | 2002-05-23 | — | — | US | disclosed |
| WO-2001038322-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2001-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020061860-A1 | Antisense oligonucleotide inhibition of specific histone deacetylase isoforms | HDAC5, HDAC1, HDAC8 | KEAP1 3467/4885IL1RN 2983/4885ERAP1 260/4885 |
| US-20040266718-A1 | Inhibition of specific histone deacetylase isoforms | HDAC1, HDAC5, HDAC3 | KEAP1 2301/4885IL1RN 3004/4885ERAP1 175/4885 |
| US-20080146623-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | HDAC1, HDAC3, HDAC11 | KEAP1 1183/4885IL1RN 2434/4885ERAP1 442/4885 |
| US-20140024608-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | HDAC1, HDAC3, HDAC11 | KEAP1 1183/4885IL1RN 2434/4885ERAP1 442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.