Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.51 |
| ▸ | MEN1 | O00255 | 10/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.51 |
| ▸ | GAA | P10253 | 9/20 | 0.51 |
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.51 |
| ▸ | HPGD | P15428 | 8/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.51 |
| ▸ | TP53 | P04637 | 4/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | SNCA | P37840 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 5/20 | 0.47 |
| ▸ | BLM | P54132 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15643361 | 0.89 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL31289554 | 0.85 | NPBWR1 (0.52) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL4497826 | 0.85 | HPGD (0.51) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL62030 | 0.84 | ALDH1A1 (0.67) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL29567848 | 0.84 | ALDH1A1 (0.67) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL31289524 | 0.81 | HDAC6 (0.54) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL13405888 | 0.80 | ALDH1A1 (0.71) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL5761334 | 0.80 | ALDH1A1 (0.68) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL28973519 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL15558207 | 0.80 | MAPT (0.46) | ALDH1A1MEN1KMT2AGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815895-B2 | Mediators of hedgehog signaling pathways, compositions and uses related hereto | CURIS, INC. (US) | 2014-08-26 | — | — | US | disclosed |
| US-8815895-B2 | Mediators of hedgehog signaling pathways, compositions and uses related hereto | CURIS, INC. (US) | 2014-08-26 | — | — | US | disclosed |
| US-8815895-B2 | Mediators of hedgehog signaling pathways, compositions and uses related hereto | CURIS, INC. (US) | 2014-08-26 | — | — | US | disclosed |
| EP-1807074-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2013-10-23 | — | — | EP | disclosed |
| EP-1807074-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2013-10-23 | — | — | EP | disclosed |
| US-20120283258-A1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED HERETO | CURIS, INC. (US) | 2012-11-08 | — | — | US | disclosed |
| US-20120283258-A1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED HERETO | CURIS, INC. (US) | 2012-11-08 | — | — | US | disclosed |
| US-20120283258-A1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED HERETO | CURIS, INC. (US) | 2012-11-08 | — | — | US | disclosed |
| US-8168653-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2012-05-01 | — | — | US | disclosed |
| US-8168653-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2012-05-01 | — | — | US | disclosed |
| US-20100317660-A1 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | GUICHERIT OIVIN M | 2010-12-16 | — | — | US | disclosed |
| US-20100317660-A1 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | GUICHERIT OIVIN M | 2010-12-16 | — | — | US | disclosed |
| US-7816369-B2 | hedgehog genes antagonists such as N-[5-(1H-benzimidazol-2-yl)-6-chloropyridin-3-yl]-2-methyl-6-(trifluoromethyl)pyridine-3-carboxamide, used as anticarcinogenic or antitumor agents | CURIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |
| US-7816369-B2 | hedgehog genes antagonists such as N-[5-(1H-benzimidazol-2-yl)-6-chloropyridin-3-yl]-2-methyl-6-(trifluoromethyl)pyridine-3-carboxamide, used as anticarcinogenic or antitumor agents | CURIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |
| US-7816369-B2 | hedgehog genes antagonists such as N-[5-(1H-benzimidazol-2-yl)-6-chloropyridin-3-yl]-2-methyl-6-(trifluoromethyl)pyridine-3-carboxamide, used as anticarcinogenic or antitumor agents | CURIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |
| US-20090012082-A1 | hedgehog genes antagonists such as N-[5-(1H-benzimidazol-2-yl)-6-chloropyridin-3-yl]-2-methyl-6-(trifluoromethyl)pyridine-3-carboxamide, used as anticarcinogenic or antitumor agents | CURIS, INC. (US) | 2009-01-08 | — | — | US | disclosed |
| US-20090012082-A1 | hedgehog genes antagonists such as N-[5-(1H-benzimidazol-2-yl)-6-chloropyridin-3-yl]-2-methyl-6-(trifluoromethyl)pyridine-3-carboxamide, used as anticarcinogenic or antitumor agents | CURIS, INC. (US) | 2009-01-08 | — | — | US | disclosed |
| US-20090012082-A1 | hedgehog genes antagonists such as N-[5-(1H-benzimidazol-2-yl)-6-chloropyridin-3-yl]-2-methyl-6-(trifluoromethyl)pyridine-3-carboxamide, used as anticarcinogenic or antitumor agents | CURIS, INC. (US) | 2009-01-08 | — | — | US | disclosed |
| EP-1807074-A1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | Curis, Inc. (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006050506-A1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | CURIS, INC. (US) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317660-A1 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | SHH, SMO, GLI1 | ALDH1A1 3536/4885MEN1 1195/4885KMT2A 2823/4885 |
| US-20090012082-A1 | hedgehog genes antagonists such as N-[5-(1H-benzimidazol-2-yl)-6-chloropyridin-3-yl]-2-methyl-6-(trifluoromethyl)pyridine-3-carboxamide, used as anticarcinogenic or antitumor agents | GLI1, SHH, SMO | ALDH1A1 2356/4885MEN1 3027/4885KMT2A 367/4885 |
| US-20120283258-A1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED HERETO | SHH, SMO, GLI1 | ALDH1A1 3795/4885MEN1 1166/4885KMT2A 2394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.