Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 10/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | NPC1 | O15118 | 9/20 | 0.51 |
| ▸ | RAB9A | P51151 | 9/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | GAA | P10253 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.51 |
| ▸ | TP53 | P04637 | 6/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | SNCA | P37840 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4496081 | 0.91 | ALDH1A1 (0.57) | HPGDALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30863444 | 0.91 | ALDH1A1 (0.57) | HPGDALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4496268 | 0.86 | ALDH1A1 (0.66) | HPGDALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2690716 | 0.85 | ALDH1A1 (0.51) | HPGDALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31289554 | 0.85 | NPBWR1 (0.52) | HPGDALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31289524 | 0.84 | HDAC6 (0.54) | HPGDALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10041675 | 0.84 | NPC1 (0.62) | HPGDALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22956044 | 0.84 | KDM4E (0.59) | HPGDALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7393988 | 0.84 | F7 (0.55) | HPGDALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL13405888 | 0.83 | ALDH1A1 (0.71) | HPGDALDH1A1NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482373-B2 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-20070027200-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2007-02-01 | — | — | US | disclosed |
| US-7132439-B2 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2006-11-07 | — | — | US | disclosed |
| US-20040029925-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2004-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027200-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | KCNJ2, KCNA3, KCNB2 | HPGD 3236/4885ALDH1A1 2373/4885NPC1 1216/4885 |
| US-20040029925-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | KCNJ2, KCNA3, KCNB2 | HPGD 3236/4885ALDH1A1 2373/4885NPC1 1216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.