Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL66706 | 0.83 | KDM4E (0.37) | KDM4EALDH1A1PKMTDP1CYP1A2 | |
| Acetic Acid SCHEMBL16498836 | 0.82 | KDM4E (0.41) | KDM4EALDH1A1PKMTDP1CYP1A2 | |
| SCHEMBL22587458 | 0.81 | KDM4E (0.43) | KDM4EALDH1A1PKMTDP1CYP1A2 | |
| SCHEMBL92858 | 0.81 | KDM4E (0.43) | KDM4EALDH1A1PKMTDP1CYP1A2 | |
| SCHEMBL11571280 | 0.80 | KDM4E (0.38) | KDM4EALDH1A1PKMTDP1CYP1A2 | |
| SCHEMBL13288932 | 0.79 | KDM4E (0.39) | KDM4EALDH1A1PKMTDP1CYP1A2 | |
| SCHEMBL2145456 | 0.79 | KDM4E (0.39) | KDM4EALDH1A1PKMTDP1CYP1A2 | |
| SCHEMBL11456470 | 0.79 | KDM4E (0.36) | KDM4EALDH1A1PKMTDP1CYP1A2 | |
| SCHEMBL14044378 | 0.79 | KDM4E (0.42) | KDM4EALDH1A1PKMTDP1CYP1A2 | |
| SCHEMBL2769747 | 0.79 | BRD4 (0.40) | KDM4EALDH1A1PKMTDP1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2478355-B1 | METHODS FOR DETECTING AUTODIGESTION | UNIV CALIFORNIA (US) | 2018-11-14 | — | — | EP | claimed |
| US-20120196935-A1 | METHODS FOR DETECTING AUTODIGESTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-08-02 | — | — | US | claimed |
| EP-2478355-A1 | METHODS FOR DETECTING AUTODIGESTION | The Regents of The University of California (US) | 2012-07-25 | — | — | EP | claimed |
| US-20120115177-A1 | Compositions and Methods for Diagnosis of Shock | ANAZYME, LLC (US) | 2012-05-10 | — | — | US | claimed |
| WO-2011034539-A1 | METHODS FOR DETECTING AUTODIGESTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-03-24 | — | — | WO | claimed |
| WO-2010087874-A1 | COMPOSITIONS AND METHODS FOR DIAGNOSIS OF SHOCK | ANAZYME, LLC (US) | 2010-08-05 | — | — | WO | claimed |
| US-20210139946-A9 | COMPOSITIONS AND METHODS FOR DIAGNOSIS OF SHOCK | ANAZYME | 2021-05-13 | — | — | US | disclosed |
| US-20210053997-A1 | TRNA SYNTHETASE INHIBITORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2021-02-25 | — | — | US | disclosed |
| US-20190002952-A1 | COMPOSITIONS AND METHODS FOR DIAGNOSIS OF SHOCK | ANAZYME (US) | 2019-01-03 | — | — | US | disclosed |
| EP-2478355-B1 | METHODS FOR DETECTING AUTODIGESTION | UNIV CALIFORNIA (US) | 2018-11-14 | — | — | EP | disclosed |
| US-20120196935-A1 | METHODS FOR DETECTING AUTODIGESTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-08-02 | — | — | US | disclosed |
| EP-2478355-A1 | METHODS FOR DETECTING AUTODIGESTION | The Regents of The University of California (US) | 2012-07-25 | — | — | EP | disclosed |
| US-20120115177-A1 | Compositions and Methods for Diagnosis of Shock | ANAZYME, LLC (US) | 2012-05-10 | — | — | US | disclosed |
| EP-2366704-A1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-09-21 | — | — | EP | disclosed |
| EP-2364984-A1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-09-14 | — | — | EP | disclosed |
| WO-2011034539-A1 | METHODS FOR DETECTING AUTODIGESTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-03-24 | — | — | WO | disclosed |
| WO-2010087874-A1 | COMPOSITIONS AND METHODS FOR DIAGNOSIS OF SHOCK | ANAZYME, LLC (US) | 2010-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210053997-A1 | TRNA SYNTHETASE INHIBITORS | TRMT1, AARS1, GARS1 | KDM4E 1512/4885ALDH1A1 2254/4885PKM 3635/4885 |
| US-20120196935-A1 | METHODS FOR DETECTING AUTODIGESTION | ELANE, PGA5, CD63 | KDM4E 4391/4885ALDH1A1 2531/4885PKM 3711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.