Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 6/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | NCK1 | P16333 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14142666 | 0.81 | CYP2A6 (0.48) | CYP2A6CYP1A2ALDH1A1PTPN1KDM4E | |
| SCHEMBL8149747 | 0.80 | CYP1A2 (0.68) | CYP2A6CYP1A2ALDH1A1PTPN1KDM4E | |
| SCHEMBL29387108 | 0.78 | ALDH1A1 (0.50) | CYP2A6CYP1A2ALDH1A1KDM4EGAA | |
| SCHEMBL135760 | 0.78 | SRC (0.47) | CYP2A6ALDH1A1KDM4EGAAPRKDC | |
| SCHEMBL31540801 | 0.78 | SRC (0.47) | CYP2A6ALDH1A1KDM4EGAAPRKDC | |
| SCHEMBL136361 | 0.78 | ALDH1A1 (0.50) | CYP2A6CYP1A2ALDH1A1KDM4EGAA | |
| SCHEMBL15105262 | 0.78 | LMNA (0.46) | CYP2A6ALDH1A1GAAPRKDCLMNA | |
| SCHEMBL16355662 | 0.78 | CYP2A6 (0.48) | CYP2A6CYP1A2ALDH1A1KDM4EGAA | |
| SCHEMBL3573844 | 0.75 | ALDH1A1 (0.45) | CYP2A6CYP1A2ALDH1A1KDM4EGAA | |
| SCHEMBL10680003 | 0.74 | CYP1A2 (0.59) | CYP2A6CYP1A2ALDH1A1PTPN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9334295-B2 | Fused aromatic PTP-1B inhibitors | KANEQ PHARMA INC. (CA) | 2016-05-10 | — | — | US | disclosed |
| US-9334295-B2 | Fused aromatic PTP-1B inhibitors | KANEQ PHARMA INC. (CA) | 2016-05-10 | — | — | US | disclosed |
| US-9334295-B2 | Fused aromatic PTP-1B inhibitors | KANEQ PHARMA INC. (CA) | 2016-05-10 | — | — | US | disclosed |
| EP-2114971-B1 | FUSED AROMATIC PTP-1B INHIBITORS | KANEQ PHARMA INC (CA) | 2015-06-17 | — | — | EP | disclosed |
| CN-102317296-B | Fused aromatic PTP-1B inhibitors | KANEQ PHARMA INC | 2015-05-27 | — | — | CN | disclosed |
| US-20150045325-A1 | FUSED AROMATIC PTP-1B INHIBITORS | KANEQ PHARMA INC. (CA) | 2015-02-12 | — | — | US | disclosed |
| US-20150045325-A1 | FUSED AROMATIC PTP-1B INHIBITORS | KANEQ PHARMA INC. (CA) | 2015-02-12 | — | — | US | disclosed |
| US-20150045325-A1 | FUSED AROMATIC PTP-1B INHIBITORS | KANEQ PHARMA INC. (CA) | 2015-02-12 | — | — | US | disclosed |
| US-8927526-B2 | Fused aromatic PTP-1B inhibitors | KANEQ PHARMA INC. (CA) | 2015-01-06 | — | — | US | disclosed |
| US-8927526-B2 | Fused aromatic PTP-1B inhibitors | KANEQ PHARMA INC. (CA) | 2015-01-06 | — | — | US | disclosed |
| US-20120178679-A1 | FUSED AROMATIC PTP-IB INHIBITORS | KANEQ PHARMA INC. (CA) | 2012-07-12 | — | — | US | disclosed |
| US-20120178679-A1 | FUSED AROMATIC PTP-IB INHIBITORS | KANEQ PHARMA INC. (CA) | 2012-07-12 | — | — | US | disclosed |
| US-20120178679-A1 | FUSED AROMATIC PTP-IB INHIBITORS | KANEQ PHARMA INC. (CA) | 2012-07-12 | — | — | US | disclosed |
| US-8168815-B2 | Fused aromatic PTP-1B inhibitors | KANEQ PHARMA INC. (CA) | 2012-05-01 | — | — | US | disclosed |
| US-8168815-B2 | Fused aromatic PTP-1B inhibitors | KANEQ PHARMA INC. (CA) | 2012-05-01 | — | — | US | disclosed |
| CN-102317296-A | Fused aromatic PTP-1B inhibitors | MERCK FROSST CANADA LTD | 2012-01-11 | — | — | CN | disclosed |
| US-20100022477-A1 | FUSED AROMATIC PTP-1B INHIBITORS | KANEQ PHARMA INC. (CA) | 2010-01-28 | — | — | US | disclosed |
| US-20100022477-A1 | FUSED AROMATIC PTP-1B INHIBITORS | KANEQ PHARMA INC. (CA) | 2010-01-28 | — | — | US | disclosed |
| EP-2114971-A1 | FUSED AROMATIC PTP-1B INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008089581-A1 | FUSED AROMATIC PTP-1B INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2008-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178679-A1 | FUSED AROMATIC PTP-IB INHIBITORS | PTPRF, PTPRJ, PTPRCAP | CYP2A6 1896/4885CYP1A2 2824/4885ALDH1A1 470/4885 |
| US-20150045325-A1 | FUSED AROMATIC PTP-1B INHIBITORS | PTPRJ, PTPRF, PTPRCAP | CYP2A6 1967/4885CYP1A2 2626/4885ALDH1A1 404/4885 |
| US-20100022477-A1 | FUSED AROMATIC PTP-1B INHIBITORS | PTPRJ, PTPRF, PTPRCAP | CYP2A6 1967/4885CYP1A2 2626/4885ALDH1A1 404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.