Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.45 |
| ▸ | NOS1 | P29475 | 3/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.44 |
| ▸ | CLK2 | P49760 | 4/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14867652 | 0.88 | INSR (0.50) | MAPK1NOS1MEN1KMT2AMETAP2 | |
| SCHEMBL13605404 | 0.82 | MAPK1 (0.58) | MAPK1MAOBROCK2ROCK1NOS1 | |
| SCHEMBL12867017 | 0.79 | ROCK1 (0.53) | MAPK1MAOBROCK2ROCK1NOS1 | |
| SCHEMBL10210705 | 0.79 | MAPK1 (0.62) | MAPK1MAOBROCK2ROCK1NOS1 | |
| SCHEMBL764032 | 0.76 | CDC7 (0.55) | MAPK1MAOBROCK2ROCK1NOS1 | |
| SCHEMBL4569259 | 0.76 | NOS1 (0.46) | MAPK1MAOBROCK2ROCK1NOS1 | |
| SCHEMBL21387793 | 0.76 | MAPK1 (0.71) | MAPK1MAOBROCK2ROCK1CSNK2A1 | |
| SCHEMBL8666610 | 0.76 | NOS1 (0.57) | MAPK1MAOBROCK2ROCK1NOS1 | |
| SCHEMBL10165007 | 0.76 | MAPK1 (0.62) | MAPK1MAOBROCK2ROCK1CSNK2A1 | |
| SCHEMBL25097633 | 0.75 | NOS1 (0.45) | MAPK1MAOBROCK2ROCK1NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134004-B2 | Substituted N-bicyclicalkyl bicycliccarboxyamide compounds | PFIZER INC. (US) | 2012-03-13 | — | — | US | disclosed |
| US-20090253740-A1 | SUBSTITUTED N-BICYCLICALKYL BICYCLICCARBOXYAMIDE COMPOUNDS | PFIZER INC | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253740-A1 | SUBSTITUTED N-BICYCLICALKYL BICYCLICCARBOXYAMIDE COMPOUNDS | OPRL1, CNR1, TRPV1 | MAPK1 1388/4885MAOB 2729/4885ROCK2 4650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.