Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | NOS1 | P29475 | 3/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.49 |
| ▸ | CLK2 | P49760 | 4/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.49 |
| ▸ | PRKACA | P17612 | 2/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.49 |
| ▸ | PRKX | P51817 | 2/20 | 0.49 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.49 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10210529 | 0.86 | INSR (0.54) | MAPK1NOS1CLK4CLK2DYRK1A | |
| SCHEMBL13605404 | 0.83 | MAPK1 (0.58) | MAPK1NOS1MAOBCLK4CLK2 | |
| SCHEMBL8666610 | 0.80 | NOS1 (0.57) | MAPK1NOS1MAOBCLK4CLK2 | |
| SCHEMBL269208 | 0.79 | MAPK1 (0.55) | MAPK1NOS1MAOBCLK4CLK2 | |
| SCHEMBL18669009 | 0.77 | ROCK2 (0.56) | MAPK1NOS1MAOBCLK4CLK2 | |
| SCHEMBL27998026 | 0.77 | MAPK1 (0.56) | MAPK1NOS1MAOBCLK4CLK2 | |
| SCHEMBL764032 | 0.77 | CDC7 (0.55) | MAPK1NOS1MAOBCLK4CLK2 | |
| SCHEMBL264211 | 0.77 | ROCK2 (0.58) | MAPK1NOS1MAOBCLK4CLK2 | |
| SCHEMBL8805964 | 0.77 | MAPK1 (0.54) | MAPK1NOS1MAOBCLK4CLK2 | |
| SCHEMBL29728756 | 0.77 | ROCK2 (0.58) | MAPK1NOS1MAOBCLK4CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-7795245-B2 | Heterobicyclic metalloprotease inhibitors | Atlantos Pharmaceuticals Holding, Inc. (US) | 2010-09-14 | — | — | US | disclosed |
| US-20090312312-A1 | Heterobicyclic Metalloprotease Inhibitors | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2009-12-17 | — | — | US | disclosed |
| US-20090137547-A1 | Heterobicyclic metalloprotease inhibitors | ALANTOS PHARMACEUTICALS HOLDING, INC. | 2009-05-28 | — | — | US | disclosed |
| US-20070155738-A1 | Heterobicyclic metalloprotease inhibitors | ALANTOS PHARMACEUTICALS, INC. | 2007-07-05 | — | — | US | disclosed |
| US-20070155738-A1 | Heterobicyclic metalloprotease inhibitors | ALANTOS PHARMACEUTICALS, INC. | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312312-A1 | Heterobicyclic Metalloprotease Inhibitors | MMP13, TIMP3, MMP3 | MAPK1 2860/4885NOS1 3716/4885MAOB 273/4885 |
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | MMP13, TIMP3, MMP3 | MAPK1 2860/4885NOS1 3716/4885MAOB 273/4885 |
| US-20090137547-A1 | Heterobicyclic metalloprotease inhibitors | MMP13, TIMP3, MMP3 | MAPK1 2860/4885NOS1 3716/4885MAOB 273/4885 |
| US-20070155738-A1 | Heterobicyclic metalloprotease inhibitors | MMP13, TIMP3, MMP3 | MAPK1 2860/4885NOS1 3716/4885MAOB 273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.