Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 6/20 | 0.35 |
| ▸ | GABBR1 | Q9UBS5 | 6/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26922749 | 1.00 | GABBR2 (0.35) | GABBR2GABBR1LMNACYP2C9TSHR | |
| SCHEMBL26923223 | 1.00 | GABBR2 (0.35) | GABBR2GABBR1LMNACYP2C9TSHR | |
| SCHEMBL11080457 | 0.86 | TSHR (0.42) | GABBR2GABBR1LMNACYP2C9TSHR | |
| SCHEMBL12646232 | 0.86 | TSHR (0.42) | LMNATSHRCYP3A4MEN1KMT2A | |
| SCHEMBL26947352 | 0.80 | AOC3 (0.44) | GABBR2GABBR1 | |
| SCHEMBL16771268 | 0.80 | TSHR (0.36) | LMNATSHRMEN1KMT2AMAPT | |
| SCHEMBL16770710 | 0.80 | TSHR (0.36) | LMNATSHRMEN1KMT2AMAPT | |
| SCHEMBL19803214 | 0.78 | GABBR2 (0.56) | GABBR2GABBR1LMNACYP2C9TSHR | |
| SCHEMBL19803301 | 0.78 | GABBR2 (0.56) | GABBR2GABBR1LMNACYP2C9TSHR | |
| SCHEMBL6278627 | 0.78 | GABBR2 (0.56) | GABBR2GABBR1LMNACYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4316504-A2 | COMPOUNDS | Spero Therapeutics, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| EP-3810633-B1 | COMPOUNDS | SPERO THERAPEUTICS INC (US) | 2023-12-13 | — | — | EP | disclosed |