Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.32 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | GRN | P28799 | 1/20 | 0.32 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16771268 | 1.00 | TSHR (0.36) | TSHRMAPTMEN1KMT2AGABRA1 | |
| SCHEMBL12646232 | 0.88 | TSHR (0.42) | TSHRMAPTMEN1KMT2AGABRA1 | |
| SCHEMBL26922751 | 0.80 | GABBR2 (0.35) | TSHRMAPTMEN1KMT2ALMNA | |
| SCHEMBL26922749 | 0.80 | GABBR2 (0.35) | TSHRMAPTMEN1KMT2ALMNA | |
| SCHEMBL21164276 | 0.80 | TSHR (0.35) | TSHRMAPTMEN1KMT2AESR1 | |
| SCHEMBL26923223 | 0.80 | GABBR2 (0.35) | TSHRMAPTMEN1KMT2ALMNA | |
| SCHEMBL11225092 | 0.80 | GABBR2 (0.43) | TSHRMAPTMEN1KMT2ALMNA | |
| SCHEMBL16770812 | 0.80 | TSHR (0.35) | TSHRMAPTMEN1KMT2AAKR1B10 | |
| SCHEMBL18713913 | 0.77 | RAPGEF4 (0.36) | TSHRADRA2AADRA2BADRA2C | |
| SCHEMBL23159252 | 0.77 | ALDH1A1 (0.35) | TSHRMAPTMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015078374-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2015-06-04 | — | — | WO | disclosed |