Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | GABBR2 | O75899 | 5/20 | 0.38 |
| ▸ | GABBR1 | Q9UBS5 | 5/20 | 0.38 |
| ▸ | ACP3 | P15309 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26923060 | 1.00 | PNMT (0.39) | PNMTGABBR2GABBR1ACP3AOC3 | |
| SCHEMBL11080398 | 0.84 | PNMT (0.48) | PNMTGABBR2GABBR1ACP3AOC3 | |
| SCHEMBL26922629 | 0.80 | HTR2A (0.41) | GABBR2GABBR1TAAR1MGAMGAA | |
| SCHEMBL26922035 | 0.80 | HTR2A (0.41) | GABBR2GABBR1TAAR1MGAMGAA | |
| SCHEMBL31332655 | 0.79 | PNMT (0.44) | PNMTGABBR2GABBR1ACP3AOC3 | |
| SCHEMBL31332659 | 0.79 | PNMT (0.44) | PNMTGABBR2GABBR1ACP3AOC3 | |
| SCHEMBL26923676 | 0.79 | GABBR2 (0.56) | GABBR2GABBR1MEN1KMT2ALMNA | |
| SCHEMBL26922771 | 0.79 | GABBR2 (0.56) | GABBR2GABBR1MEN1KMT2ALMNA | |
| SCHEMBL18382609 | 0.79 | GABBR2 (0.56) | GABBR2GABBR1MEN1KMT2ALMNA | |
| SCHEMBL19812664 | 0.78 | GABBR2 (0.55) | GABBR2GABBR1MEN1KMT2ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4316504-A2 | COMPOUNDS | Spero Therapeutics, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| EP-3810633-B1 | COMPOUNDS | SPERO THERAPEUTICS INC (US) | 2023-12-13 | — | — | EP | disclosed |