Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.35 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | AGXT | P21549 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26922035 | 1.00 | HTR2A (0.41) | HTR2AIDO1TDO2ALDH1A1TAAR1 | |
| SCHEMBL2169566 | 0.90 | ALDH1A1 (0.44) | IDO1TDO2ALDH1A1MGAMGAA | |
| SCHEMBL11078413 | 0.84 | IDO1 (0.52) | HTR2AIDO1TDO2ALDH1A1TAAR1 | |
| SCHEMBL26923060 | 0.80 | PNMT (0.39) | TAAR1MGAMGAASIMGAM2 | |
| SCHEMBL26922943 | 0.80 | PNMT (0.39) | TAAR1MGAMGAASIMGAM2 | |
| SCHEMBL19812664 | 0.78 | GABBR2 (0.55) | HTR2ATAAR1GABBR2GABBR1 | |
| SCHEMBL5775168 | 0.77 | IDO1 (0.42) | HTR2AIDO1TDO2ALDH1A1TAAR1 | |
| SCHEMBL2793025 | 0.76 | PARP1 (0.43) | IDO1TDO2ALDH1A1GBA1PARP1 | |
| SCHEMBL2794383 | 0.76 | PARP1 (0.43) | IDO1TDO2ALDH1A1GBA1PARP1 | |
| SCHEMBL2793022 | 0.76 | PARP1 (0.43) | IDO1TDO2ALDH1A1GBA1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4316504-A2 | COMPOUNDS | Spero Therapeutics, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| EP-3810633-B1 | COMPOUNDS | SPERO THERAPEUTICS INC (US) | 2023-12-13 | — | — | EP | disclosed |