Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 5/20 | 0.37 |
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 4/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18521895 | 0.89 | KDM4A (0.43) | KDM4AKCNA5RIPK1HDAC10HDAC6 | |
| SCHEMBL23105674 | 0.83 | P2RX7 (0.48) | KDM4AKCNA5RIPK1HDAC10HDAC6 | |
| SCHEMBL16971616 | 0.83 | IDO1 (0.51) | KDM4AKCNA5HDAC10HDAC6IDO1 | |
| SCHEMBL2446141 | 0.82 | EPHX2 (0.46) | KDM4AKCNA5RIPK1HDAC10HDAC6 | |
| SCHEMBL6950153 | 0.82 | HDAC10 (0.43) | KDM4AKCNA5RIPK1HDAC10HDAC6 | |
| SCHEMBL31704494 | 0.81 | CACNA1H (0.46) | KDM4AKCNA5RIPK1HDAC10HDAC6 | |
| SCHEMBL2441663 | 0.81 | NOTUM (0.48) | KDM4AKCNA5RIPK1HDAC10HDAC6 | |
| SCHEMBL30101811 | 0.81 | KDM4A (0.43) | KDM4AKCNA5HDAC10HDAC6IDO1 | |
| SCHEMBL30101874 | 0.81 | KDM4A (0.43) | KDM4AKCNA5RIPK1IDO1HDAC1 | |
| SCHEMBL1329466 | 0.80 | RIPK1 (0.60) | KDM4AKCNA5RIPK1HDAC10HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239645-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023239645-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |