SCHEMBL6950153

SCHEMBL6950153

CC(C)(C)OC(=O)NCc1ccc(C(=O)OC(C)(C)C)cc1Br

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC10 Q969S8 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
KDM4A O75164 1/20 0.42
NAMPT P43490 1/20 0.40
NOTUM Q6P988 1/20 0.40
HDAC1 Q13547 1/20 0.39
KCNA5 P22460 1/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA9 Q16790 1/20 0.39
CA14 Q9ULX7 1/20 0.39
RIPK1 Q13546 1/20 0.38
GABRA1 P14867 1/20 0.38
GABRG2 P18507 1/20 0.38
GABRB3 P28472 1/20 0.38
GABRA3 P34903 1/20 0.38
GABRA2 P47869 1/20 0.38
IDO1 P14902 2/20 0.37
P4HB P07237 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2441663 0.93 NOTUM (0.48) HDAC10HDAC6KDM4ANAMPTNOTUM
SCHEMBL2446141 0.89 EPHX2 (0.46) HDAC10HDAC6KDM4ANAMPTHDAC1
SCHEMBL7665459 0.84 ALOX15 (0.46) HDAC10HDAC6KDM4ANAMPTHDAC1
SCHEMBL28994237 0.83 HDAC10 (0.40) HDAC10HDAC6KDM4ANAMPTNOTUM
SCHEMBL12230860 0.83 NOTUM (0.45) HDAC10HDAC6KDM4ANAMPTNOTUM
SCHEMBL23105674 0.82 P2RX7 (0.48) HDAC10HDAC6KDM4AKCNA5CA12
SCHEMBL26932253 0.82 KDM4A (0.43) HDAC10HDAC6KDM4ANAMPTHDAC1
SCHEMBL16971616 0.82 IDO1 (0.51) HDAC10HDAC6KDM4AKCNA5IDO1
SCHEMBL3526985 0.81 CA12 (0.43) NOTUMCA12CA1CA2CA9
SCHEMBL15862086 0.81 KDM4A (0.44) HDAC10HDAC6KDM4ANAMPTNOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0674623-B1 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2003-04-09 EP disclosed
US-6403578-B1 ANTICOAGULANTS, CARDIOVASCULAR DISORDERS SMITHKLINE BEECHAM CORPORATION 2002-06-11 US disclosed
EP-0674623-A1 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1995-10-04 EP disclosed
WO-1994014776-A2 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1994-07-07 WO disclosed