Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 4/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26933602 | 1.00 | KDM1A (0.47) | KDM1AKIF11IDO1DAOCYP11B1 | |
| SCHEMBL30636293 | 1.00 | KDM1A (0.47) | KDM1AKIF11IDO1DAOCYP11B1 | |
| Hydrochloric Acid SCHEMBL30636281 | 0.99 | KDM1A (0.46) | KDM1AKIF11IDO1DAOCYP11B1 | |
| SCHEMBL26933298 | 0.83 | GRM2 (0.44) | SLC6A4DRD4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL26933291 | 0.83 | GRM2 (0.44) | SLC6A4DRD4SLC6A2SLC6A3KCNH2 | |
| Hydrochloric Acid SCHEMBL30636343 | 0.82 | GRM2 (0.43) | SLC6A4DRD4SLC6A2SLC6A3KCNH2 | |
| Hydrochloric Acid SCHEMBL21491497 | 0.82 | GRM2 (0.43) | SLC6A4DRD4SLC6A2SLC6A3KCNH2 | |
| Hydrochloric Acid SCHEMBL21491496 | 0.82 | GRM2 (0.43) | SLC6A4DRD4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL3122265 | 0.79 | KIF11 (0.39) | KDM1AKIF11DAOSLC6A4DRD4 | |
| SCHEMBL26933269 | 0.78 | EPHX2 (0.42) | KIF11FFAR1DRD4MGLLGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313951-A1 | 1,3-SUBSTITUTED CYCLOBUTYL DERIVATIVES AND USES THEREOF | Novartis AG (CH) | 2024-02-07 | — | — | EP | disclosed |
| US-11845730-B2 | 1,3-substituted cyclobutyl derivatives and uses thereof | CITIBANK, N.A., AS NOTES COLLATERAL AGENT | 2023-12-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11845730-B2 | 1,3-substituted cyclobutyl derivatives and uses thereof | TRPV1, TRPV3, TRPV2 | KDM1A 4513/4885KIF11 4205/4885IDO1 584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.