SCHEMBL26935872

SCHEMBL26935872

CC[Si](C)(CC)c1cc2ccccc2c2c1op(N(C(C)C)C(C)C)oc1ccc3ccccc3c12

nearest known ligand 0.31

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 2/20 0.31
▸ KDM4E B2RXH2 1/20 0.31
▸ MEN1 O00255 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ LMNA P02545 1/20 0.31
▸ MAPT P10636 1/20 0.31
▸ HPGD P15428 1/20 0.31
▸ HTT P42858 1/20 0.31
▸ NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26935812 0.92 TSHR (0.31) —
SCHEMBL24176706 0.90 — —
SCHEMBL26935816 0.89 CYP1A2 (0.31) KMT2AKDM4EMEN1ALDH1A1LMNA
SCHEMBL24176504 0.85 KMT2A (0.31) KMT2A
SCHEMBL13296135 0.82 HPGD (0.38) KMT2AKDM4EMEN1ALDH1A1LMNA
SCHEMBL24176530 0.82 MAPT (0.33) KMT2AKDM4EMEN1ALDH1A1LMNA
SCHEMBL24176529 0.82 KMT2A (0.31) KMT2AKDM4EMEN1ALDH1A1LMNA
SCHEMBL26935817 0.81 — —
SCHEMBL26935813 0.81 CACNA2D1 (0.31) —
SCHEMBL26935883 0.81 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11840550-B2 Silyl-biaryl phosphoramidites and methods of making BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2023-12-12 — — US disclosed
US-11840550-B2 Silyl-biaryl phosphoramidites and methods of making BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2023-12-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11840550-B2 Silyl-biaryl phosphoramidites and methods of making PAICS, PGLS, SCLY KMT2A 1728/4885KDM4E 3107/4885MEN1 1703/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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