Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 4/20 | 0.36 |
| ▸ | RNPEP | Q9H4A4 | 3/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 2/20 | 0.34 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27120254 | 1.00 | PLA2G10 (0.42) | PLA2G10ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL28681574 | 0.83 | PLA2G10 (0.50) | PLA2G10ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL27905207 | 0.83 | ALDH1A1 (0.48) | PLA2G10ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL25291547 | 0.83 | ALDH1A1 (0.42) | PLA2G10ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL27651567 | 0.83 | ALDH1A1 (0.42) | PLA2G10ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL3306198 | 0.83 | ALDH1A1 (0.42) | PLA2G10ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL34469833 | 0.82 | ALDH1A1 (0.31) | ALDH1A1FOLH1 | |
| Benzene SCHEMBL28850626 | 0.79 | CNR1 (0.43) | ALDH1A1LMNAMEN1KMT2AMME | |
| SCHEMBL16329867 | 0.78 | TAS1R3 (0.44) | PLA2G10ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL4284738 | 0.78 | CA2 (0.39) | LMNATAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230406860-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | AMGEN INC. | 2023-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230406860-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | KRAS, NRAS, HRAS | PLA2G10 2367/4885ALDH1A1 1457/4885LMNA 2655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.