Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 5/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 6/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.42 |
| ▸ | GNRHR | P30968 | 1/20 | 0.42 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.41 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 3/20 | 0.40 |
| ▸ | F13A1 | P00488 | 2/20 | 0.40 |
| ▸ | TGM1 | P22735 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26969702 | 0.93 | GNRHR (0.47) | RORCHDAC1HDAC8HDAC6TACR1 | |
| SCHEMBL25236263 | 0.91 | HDAC1 (0.53) | HDAC1HDAC8HDAC6TACR1P2RY1 | |
| SCHEMBL25281390 | 0.86 | TACR1 (0.48) | RORCHDAC1HDAC8HDAC6TACR1 | |
| SCHEMBL30412880 | 0.86 | HDAC1 (0.45) | RORCHDAC1HDAC8HDAC6TACR1 | |
| SCHEMBL25229091 | 0.86 | HDAC1 (0.45) | RORCHDAC1HDAC8HDAC6TACR1 | |
| SCHEMBL25275694 | 0.85 | RORC (0.44) | RORCHDAC1HDAC8HDAC6TACR1 | |
| SCHEMBL26969769 | 0.84 | HDAC1 (0.44) | RORCHDAC1HDAC8HDAC6TACR1 | |
| SCHEMBL26969700 | 0.84 | HDAC1 (0.46) | HDAC1HDAC8HDAC6TACR1P2RY1 | |
| SCHEMBL30413532 | 0.83 | HDAC1 (0.42) | RORCHDAC1HDAC8HDAC6TACR1 | |
| SCHEMBL25228295 | 0.83 | HDAC1 (0.42) | RORCHDAC1HDAC8HDAC6TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. | 2023-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | TRPM2, TRPM4, TRPM5 | RORC 2737/4885HDAC1 2067/4885HDAC8 1532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.