Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.34 |
| ▸ | PRF1 | P14222 | 2/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26969760 | 0.82 | ACLY (0.38) | ACLYALDH1A1TSHRNOTUMHSD17B10 | |
| SCHEMBL25276068 | 0.80 | KMT2A (0.43) | ACLYALDH1A1TSHRNOTUMTP53 | |
| SCHEMBL30733423 | 0.76 | KCNN4 (0.47) | ACLYALDH1A1NOTUMPKMKCNN4 | |
| SCHEMBL30733401 | 0.76 | NOTUM (0.45) | ACLYNOTUMNPY5R | |
| SCHEMBL25282082 | 0.76 | ACLY (0.40) | ACLYALDH1A1NOTUMPKMATM | |
| SCHEMBL25238614 | 0.75 | NOTUM (0.42) | ACLYALDH1A1NOTUMNPY5RKCNN4 | |
| SCHEMBL25281852 | 0.75 | MEN1 (0.54) | ACLYALDH1A1NOTUMATMNPY5R | |
| SCHEMBL29386556 | 0.75 | MEN1 (0.54) | ACLYALDH1A1NOTUMATMNPY5R | |
| SCHEMBL30733408 | 0.75 | KMT2A (0.43) | ACLYTSHRNOTUMHSD17B10NPY5R | |
| SCHEMBL30733405 | 0.75 | TSHR (0.50) | ACLYALDH1A1TSHRNOTUMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. | 2023-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | TRPM2, TRPM4, TRPM5 | ACLY 3265/4885BRD4 1470/4885ALDH1A1 3737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.