Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26647137 | 0.81 | MAPT (0.49) | ALDH1A1HTTPOLBMEN1KMT2A | |
| SCHEMBL30829022 | 0.81 | MAPT (0.49) | ALDH1A1HTTPOLBMEN1KMT2A | |
| SCHEMBL11642192 | 0.74 | ALDH1A1 (0.61) | ALDH1A1HTTPOLBMEN1KMT2A | |
| SCHEMBL11636549 | 0.74 | ALDH1A1 (0.57) | ALDH1A1HTTPOLBMEN1KMT2A | |
| SCHEMBL1459863 | 0.73 | ALDH1A1 (0.49) | ALDH1A1VCAM1NPC1HSD17B10SMN1; SMN2 | |
| SCHEMBL26804195 | 0.73 | NOS3 (0.47) | ALDH1A1HTTPOLBMEN1KMT2A | |
| SCHEMBL29243314 | 0.72 | ALDH1A1 (0.47) | ALDH1A1HTTPOLBMEN1KMT2A | |
| SCHEMBL15078307 | 0.72 | SMN1; SMN2 (0.45) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL11641375 | 0.71 | ALDH1A1 (0.50) | ALDH1A1HTTPOLBMEN1KMT2A | |
| SCHEMBL31481311 | 0.69 | GPR35 (0.38) | ALDH1A1HTTPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858915-B2 | Polo like kinase 4 inhibitors | ORIC PHARMACEUTICALS, INC. (US) | 2024-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11858915-B2 | Polo like kinase 4 inhibitors | PLK4, PLK2, PLK3 | ALDH1A1 2211/4885HTT 4049/4885POLB 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.