Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26977284 | 0.90 | CDK2 (0.38) | JAK2JAK1TYK2GAAALDH1A1 | |
| SCHEMBL27240942 | 0.80 | JAK2 (0.48) | JAK2JAK1TYK2MAPTKDR | |
| SCHEMBL26977200 | 0.79 | MKNK2 (0.38) | JAK2JAK1TYK2KDRMKNK2 | |
| SCHEMBL26980190 | 0.77 | CCNT1 (0.41) | JAK2JAK1GAAALDH1A1MAPT | |
| SCHEMBL29929298 | 0.77 | CDK2 (0.41) | JAK2JAK1TYK2MAPTKMT2A | |
| SCHEMBL29929752 | 0.77 | CCNT1 (0.41) | JAK2JAK1GAAALDH1A1MAPT | |
| SCHEMBL23611886 | 0.76 | MAPT (0.43) | ALDH1A1MAPTKMT2ALMNAMEN1 | |
| SCHEMBL30053407 | 0.76 | MAPT (0.43) | ALDH1A1MAPTKMT2ALMNAMEN1 | |
| SCHEMBL29929725 | 0.75 | CCNT1 (0.41) | JAK2JAK1TYK2GAAALDH1A1 | |
| SCHEMBL26980444 | 0.75 | CCNT1 (0.41) | JAK2JAK1TYK2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4297873-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | Tyra Biosciences, Inc. (US) | 2024-01-03 | — | — | EP | disclosed |