Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 13/20 | 0.35 |
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.34 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | BUB1B | O60566 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | NPM1 | P06748 | 1/20 | 0.34 |
| ▸ | FES | P07332 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26977167 | 0.88 | LRRK2 (0.38) | MKNK2EGFRIGF1RJAK2JAK1 | |
| SCHEMBL27241026 | 0.81 | NUAK1 (0.48) | IGF1RJAK1FGFR2FGFR4FGFR3 | |
| SCHEMBL26977144 | 0.79 | JAK2 (0.38) | MKNK2EGFRJAK2JAK1TYK2 | |
| SCHEMBL26977284 | 0.74 | CDK2 (0.38) | MKNK2EGFRJAK2JAK1TYK2 | |
| SCHEMBL23611969 | 0.73 | MAPT (0.42) | MKNK2 | |
| SCHEMBL29929645 | 0.73 | MAPT (0.42) | MKNK2 | |
| SCHEMBL26977136 | 0.72 | CCND3 (0.49) | IGF1RJAK2JAK1TYK2INSR | |
| SCHEMBL26977295 | 0.71 | IGF1R (0.43) | EGFRIGF1RJAK2JAK1TYK2 | |
| SCHEMBL27240960 | 0.70 | JAK2 (0.41) | MKNK2IGF1RJAK2JAK1TYK2 | |
| SCHEMBL29929693 | 0.70 | JAK3 (0.44) | EGFRIGF1RJAK2METLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4297873-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | Tyra Biosciences, Inc. (US) | 2024-01-03 | — | — | EP | disclosed |