Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 2/20 | 0.40 |
| ▸ | CCR5 | P51681 | 2/20 | 0.40 |
| ▸ | CCR8 | P51685 | 2/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7918759 | 0.79 | POLB (0.67) | BRD4NPC1POLBRAB9ACCR1 | |
| SCHEMBL22946631 | 0.76 | KDM4E (0.59) | CCR1CCR5CCR8METAP2MMP9 | |
| SCHEMBL26174483 | 0.74 | DYRK1B (0.55) | BRD4TGFBR1 | |
| SCHEMBL26977191 | 0.74 | GRM5 (0.40) | BRD4HTTGRM5GRM1MAT2A | |
| SCHEMBL18228190 | 0.74 | MAT2A (0.40) | KDM4EBRAFGRM5GRM1MAT2A | |
| SCHEMBL9681324 | 0.73 | CCR1 (0.55) | BRD4NPC1POLBRAB9ACCR1 | |
| SCHEMBL17691832 | 0.73 | CCR1 (0.55) | BRD4NPC1POLBRAB9ACCR1 | |
| SCHEMBL29654363 | 0.73 | CCR1 (0.55) | BRD4NPC1POLBRAB9ACCR1 | |
| SCHEMBL17334526 | 0.72 | CCR1 (0.62) | BRD4NPC1POLBRAB9ACCR1 | |
| SCHEMBL23016267 | 0.70 | BRD4 (0.50) | BRD4NPC1POLBRAB9ACCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873338-A1 | QUINOLINE DERIVATIVES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | Novartis AG (CH) | 1998-10-28 | — | — | EP | disclosed |
| WO-1997018208-A1 | QUINOLINE DERIVATIVES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | NOVARTIS AG (CH) | 1997-05-22 | — | — | WO | disclosed |