SCHEMBL2700387

SCHEMBL2700387

O=C1C(=O)c2cc3c(ccc4ccccc43)cc2-c2ccccc21

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DNMT1 P26358 2/20 0.59
▸ ALDH1A1 P00352 5/20 0.54
▸ HSD17B10 Q99714 4/20 0.54
▸ HIF1A Q16665 2/20 0.54
▸ CYP1B1 Q16678 1/20 0.54
▸ HPGD P15428 3/20 0.48
▸ MAPK1 P28482 2/20 0.48
▸ TSHR P16473 2/20 0.48
▸ L3MBTL1 Q9Y468 2/20 0.48
▸ CASP1 P29466 2/20 0.48
▸ PTPRC P08575 4/20 0.48
▸ S100A4 P26447 3/20 0.48
▸ MEN1 O00255 3/20 0.48
▸ APAF1 O14727 3/20 0.48
▸ NPC1 O15118 3/20 0.48
▸ LMNA P02545 3/20 0.48
▸ HTT P42858 3/20 0.48
▸ RAB9A P51151 3/20 0.48
▸ GALK1 P51570 3/20 0.48
▸ BLM P54132 3/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7653329 0.86 ALDH1A1 (0.60) DNMT1ALDH1A1HSD17B10HIF1ACYP1B1
SCHEMBL7648181 0.83 ALDH1A1 (0.56) DNMT1ALDH1A1HSD17B10HIF1ACYP1B1
SCHEMBL2198881 0.82 PTPRC (0.65) DNMT1ALDH1A1HSD17B10HIF1AHPGD
SCHEMBL6118199 0.79 PTPRC (0.50) DNMT1ALDH1A1HSD17B10HIF1AHPGD
SCHEMBL1234836 0.79 PTPRC (0.50) DNMT1ALDH1A1HSD17B10HIF1AHPGD
SCHEMBL5145444 0.78 PTPRC (0.59) DNMT1ALDH1A1HSD17B10HIF1AHPGD
SCHEMBL29440306 0.78 MEN1 (0.60) DNMT1ALDH1A1HSD17B10HIF1AHPGD
SCHEMBL29634247 0.78 MEN1 (0.60) DNMT1ALDH1A1HSD17B10HIF1AHPGD
SCHEMBL347152 0.78 MEN1 (0.60) DNMT1ALDH1A1HSD17B10HIF1AHPGD
SCHEMBL4852349 0.77 ALDH1A1 (0.65) DNMT1ALDH1A1HSD17B10HIF1ACYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8507162-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2013-08-13 — — US disclosed
EP-2447781-B1 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KK (JP) 2013-01-16 — — EP disclosed
US-20120107735-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2012-05-03 — — US disclosed
EP-2447781-A1 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus Canon Kabushiki Kaisha (JP) 2012-05-02 — — EP disclosed
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