Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SDCBP | O00560 | 1/20 | 0.39 |
| ▸ | SDC2 | P34741 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25986702 | 0.89 | PDE4A (0.34) | MAPTMEN1KMT2APDE4APDE4B | |
| SCHEMBL27004983 | 0.88 | ITGB3 (0.36) | MAPTMEN1KMT2ASDCBPSDC2 | |
| SCHEMBL26018891 | 0.86 | THRB (0.39) | MAPTMEN1KMT2ASDCBPSDC2 | |
| SCHEMBL26020642 | 0.86 | NPC1 (0.39) | MAPTMEN1KMT2ASDCBPSDC2 | |
| SCHEMBL27006159 | 0.84 | SDCBP (0.37) | MAPTMEN1KMT2ASDCBPSDC2 | |
| SCHEMBL25993698 | 0.80 | HRH3 (0.33) | PRMT5WDR77 | |
| SCHEMBL27019018 | 0.78 | NPC1 (0.39) | MAPTMEN1KMT2ASDCBPSDC2 | |
| SCHEMBL26003966 | 0.76 | MEN1 (0.36) | MAPTMEN1KMT2ASDCBPSDC2 | |
| SCHEMBL26020707 | 0.76 | THRB (0.43) | MAPTSDCBPSDC2POLBLMNA | |
| SCHEMBL26024862 | 0.76 | SDCBP (0.42) | MAPTMEN1KMT2ASDCBPSDC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4306111-A2 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF | Novartis AG (CH) | 2024-01-17 | — | — | EP | disclosed |