Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 2/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 6/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27006549 | 0.84 | DYRK1A (0.41) | DYRK1AJAK2RETKDRGSK3A | |
| SCHEMBL27006141 | 0.82 | PDE4A (0.49) | DYRK1AJAK2EGLN2TGFBR1CYP11B1 | |
| SCHEMBL27005131 | 0.76 | KDM1A (0.47) | — | |
| SCHEMBL27005346 | 0.76 | KDM1A (0.47) | — | |
| SCHEMBL27006151 | 0.73 | EGLN2 (0.39) | EGLN2CYP11B1CYP11B2SLC22A12 | |
| SCHEMBL27005844 | 0.72 | CYP11B1 (0.45) | EGLN2CYP11B1CYP11B2 | |
| SCHEMBL27005050 | 0.70 | ESR1 (0.48) | CYP11B1CYP11B2 | |
| SCHEMBL27006058 | 0.69 | CYP11B2 (0.45) | CYP11B1CYP11B2 | |
| SCHEMBL27005607 | 0.69 | KDM1A (0.47) | CYP11B1CYP11B2 | |
| SCHEMBL27009752 | 0.68 | CYP11B1 (0.45) | EGLN2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4306520-A1 | THIOPHENE COMPOUND AND APPLICATION THEREOF | Medshine Discovery Inc. (CN) | 2024-01-17 | — | — | EP | disclosed |