Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL345674 | 0.92 | KDM4E (0.80) | KDM4EMAPK1HIF1AADRA1APAOX | |
| SCHEMBL3557960 | 0.89 | KDM4E (0.57) | KDM4EMAPK1HIF1AADRA1APAOX | |
| SCHEMBL1900471 | 0.89 | KDM4E (0.82) | KDM4EMAPK1HIF1AADRA1APAOX | |
| SCHEMBL8958360 | 0.86 | KDM4E (0.43) | KDM4EMAPK1HIF1AADRA1AALDH1A1 | |
| SCHEMBL860791 | 0.83 | KDM4E (0.94) | KDM4EMAPK1HIF1AADRA1APAOX | |
| SCHEMBL21306389 | 0.81 | PAOX (0.74) | KDM4EMAPK1HIF1AADRA1APAOX | |
| SCHEMBL1847535 | 0.80 | KDM4E (1.00) | KDM4EMAPK1HIF1AADRA1APAOX | |
| SCHEMBL14740132 | 0.80 | KDM4E (1.00) | KDM4EMAPK1HIF1AADRA1APAOX | |
| SCHEMBL1900654 | 0.80 | KDM4E (1.00) | KDM4EMAPK1HIF1AADRA1APAOX | |
| SCHEMBL10937726 | 0.80 | KDM4E (1.00) | KDM4EMAPK1HIF1AADRA1APAOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240018122-A1 | PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2024-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240018122-A1 | PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS | ALK, TGFBR1, ACVR1 | KDM4E 474/4885MAPK1 176/4885HIF1A 443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.