Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.58 |
| ▸ | TET3 | O43151 | 1/20 | 0.55 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.55 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.55 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.55 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.55 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.55 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2701832 | 0.89 | KMT2A (0.57) | KMT2ACYP2C19MEN1RAB9AAKR1C1 | |
| SCHEMBL7066460 | 0.85 | KMT2A (0.70) | KMT2ACYP2C19MEN1RAB9AAKR1C1 | |
| SCHEMBL6498727 | 0.84 | KMT2A (0.68) | KMT2ACYP2C19MEN1RAB9AAKR1C1 | |
| SCHEMBL27683261 | 0.81 | AKR1C1 (0.63) | KMT2ACYP2C19MEN1RAB9AAKR1C1 | |
| SCHEMBL2465437 | 0.79 | ALDH1A1 (0.78) | KMT2ATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL6502637 | 0.78 | KMT2A (0.61) | KMT2ACYP2C19MEN1RAB9AAKR1C1 | |
| SCHEMBL27381366 | 0.78 | KMT2A (0.65) | KMT2ACYP2C19MEN1RAB9AAKR1C1 | |
| SCHEMBL6391 | 0.78 | AKR1C1 (0.83) | KMT2ACYP2C19MEN1RAB9AAKR1C1 | |
| SCHEMBL31016196 | 0.78 | AKR1C1 (0.83) | KMT2ACYP2C19MEN1RAB9AAKR1C1 | |
| SCHEMBL23779147 | 0.77 | KMT2A (0.69) | KMT2ACYP2C19MEN1RAB9AAKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2228065-B1 | Heterocyclo inhibitors of potassium channel function | BRISTOL MYERS SQUIBB CO (US) | 2012-12-26 | — | — | EP | disclosed |
| EP-1501467-B1 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2012-05-09 | — | — | EP | disclosed |
| EP-2228065-A2 | Heterocyclo inhibitors of potassium channel function | Bristol-Myers Squibb Company (US) | 2010-09-15 | — | — | EP | disclosed |
| US-20090312307-A1 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY | 2009-12-17 | — | — | US | disclosed |
| US-7582654-B2 | Heterocyclo inhibitors of potassium channel function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-01 | — | — | US | disclosed |
| US-7005436-B2 | Heterocyclo inhibitors of potassium channel function | BRISTOL MYERS SQUIBB COMPANY (US) | 2006-02-28 | — | — | US | disclosed |
| US-20060014792-A1 | Heterocyclo inhibitors of potassium channel function | LLOYD JOHN | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014792-A1 | Heterocyclo inhibitors of potassium channel function | KCNJ2, KCNH2, KCNQ5 | KMT2A 957/4885CYP2C19 3045/4885MEN1 3501/4885 |
| US-20090312307-A1 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | KCNJ2, KCNH2, KCNQ5 | KMT2A 957/4885CYP2C19 3045/4885MEN1 3501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.