Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 4/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 6/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | CASP2 | P42575 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7399139 | 0.83 | DDB1 (0.46) | GSK3BKDM4EALDH1A1GAAHPGD | |
| SCHEMBL3435349 | 0.82 | CYP3A4 (0.44) | GSK3BKDM4EALDH1A1GAAHPGD | |
| Water SCHEMBL8678456 | 0.81 | DDB1 (0.45) | GSK3BKDM4EALDH1A1GAAHPGD | |
| SCHEMBL7648225 | 0.80 | CYP2A6 (0.43) | GSK3BKDM4EALDH1A1GAAHPGD | |
| SCHEMBL11064554 | 0.80 | KCNA3 (0.40) | GSK3BKDM4EALDH1A1GAAHPGD | |
| SCHEMBL10776993 | 0.80 | CDK2 (0.43) | GSK3BKDM4EALDH1A1GAAHPGD | |
| SCHEMBL262473 | 0.80 | GSK3B (0.50) | GSK3BKDM4EALDH1A1GAAHPGD | |
| SCHEMBL28099802 | 0.80 | GSK3B (0.50) | GSK3BKDM4EALDH1A1GAAHPGD | |
| SCHEMBL22930414 | 0.79 | CYP3A4 (0.44) | GSK3BKDM4EALDH1A1GAAHPGD | |
| SCHEMBL8133117 | 0.79 | DDB1 (0.49) | KDM4EALDH1A1GAAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448600-B1 | COMPOUNDS TARGETING THE CATION-INDEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR | INSERM INST NAT DE LA SANTÉ ET DE LA RECH MÉDICALE (FR) | 2016-03-30 | — | — | EP | disclosed |
| US-8962573-B2 | Compounds targeting the cation-independent mannose 6-phosphate receptor | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2015-02-24 | — | — | US | disclosed |
| EP-2448600-A1 | COMPOUNDS TARGETING THE CATION-INDEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR | INSERM - Institut National de la Santé et de la Recherche Médicale (FR) | 2012-05-09 | — | — | EP | disclosed |