Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.42 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.42 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | LIG1 | P18858 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2701829 | 0.82 | GSK3B (0.42) | CYP3A4GAAMEN1KMT2AHPGD | |
| SCHEMBL5919579 | 0.80 | KCNA3 (0.50) | CYP3A4CYP2A6TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL7399139 | 0.79 | DDB1 (0.46) | CYP2A6PTPRCGAAMEN1KMT2A | |
| Water SCHEMBL8678456 | 0.78 | DDB1 (0.45) | CYP2A6PTPRCGAAMEN1KMT2A | |
| SCHEMBL11064554 | 0.76 | KCNA3 (0.40) | CA1CA9GAAHPGDHSD17B10 | |
| SCHEMBL7648225 | 0.76 | CYP2A6 (0.43) | CYP2A6GAAMEN1KMT2AHPGD | |
| SCHEMBL10776993 | 0.76 | CDK2 (0.43) | GAAMEN1KMT2AHPGDHSD17B10 | |
| SCHEMBL17594770 | 0.76 | TOP1 (0.56) | CYP3A4CYP2A6TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL10663882 | 0.76 | KCNA3 (0.57) | CYP3A4CYP2A6TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL3434411 | 0.76 | CYP3A4 (0.49) | CYP3A4CYP2A6TXNRD1TXNRD3TXNRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323813-B1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | UNIV COLUMBIA (US) | 2020-08-26 | — | — | EP | disclosed |
| US-20180244603-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2018-08-30 | — | — | US | disclosed |
| EP-3323813-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | The Trustees of Columbia University in the City of New York (US) | 2018-05-23 | — | — | EP | disclosed |
| US-9969677-B2 | Histone acetyltransferase modulators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-05-15 | — | — | US | disclosed |
| EP-2654428-B1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | UNIV COLUMBIA (US) | 2018-02-14 | — | — | EP | disclosed |
| US-20170121276-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-05-04 | — | — | US | disclosed |
| EP-2654428-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | The Trustees of Columbia University in the City of New York (US) | 2013-10-30 | — | — | EP | disclosed |
| US-8361218-B2 | Coloring composition, method for production thereof, and coloring method | Dainischiseika Color & Chemicals Mfg. Co., Ltd. (JP) | 2013-01-29 | — | — | US | disclosed |
| WO-2012088420-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-06-28 | — | — | WO | disclosed |
| US-20100291359-A1 | Coloring composition, method for production thereof, and coloring method | DAINICHISEIKA COLOR & CHEMICALS MFG. CO., LTD. (JP) | 2010-11-18 | — | — | US | disclosed |
| EP-2206751-A1 | COLORING COMPOSITION, METHOD FOR PRODUCTION THEREOF, AND COLORING METHOD | Dainichiseika Color & Chemicals Mfg. Co., Ltd. (JP) | 2010-07-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180244603-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | EP300, HTT, KAT2A | CYP3A4 4801/4885CYP2A6 4806/4885TXNRD1 1020/4885 |
| US-20170121276-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | EP300, KAT2A, HTT | CYP3A4 4782/4885CYP2A6 4789/4885TXNRD1 1022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.