Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | CCND2 | P30279 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 1/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.48 |
| ▸ | KCNH3 | Q9ULD8 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18590747 | 0.85 | HDAC3 (0.61) | AURKAHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22191032 | 0.80 | AURKA (0.56) | AURKAHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL18294906 | 0.79 | HDAC6 (0.53) | AURKAHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL27886228 | 0.78 | AURKA (0.58) | AURKAHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL24308132 | 0.77 | RAB9A (0.62) | NPC1RAB9AMEN1LMNAMAPT | |
| SCHEMBL24867246 | 0.77 | AURKA (0.53) | AURKAHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL27417170 | 0.77 | MAPT (0.63) | AURKAHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL31460972 | 0.76 | F9 (0.46) | HDAC3HDAC1HDAC2HDAC6NPC1 | |
| SCHEMBL27637976 | 0.76 | SYK (0.56) | HDAC3HDAC1HDAC2HDAC6MEN1 | |
| SCHEMBL14463321 | 0.73 | ACHE (0.68) | NPC1RAB9AMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778955-B2 | Indole derivatives or benzimidazole derivatives for modulating IkB kinase | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2014-07-15 | — | — | US | disclosed |
| US-8778955-B2 | Indole derivatives or benzimidazole derivatives for modulating IkB kinase | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2014-07-15 | — | — | US | disclosed |
| US-8778955-B2 | Indole derivatives or benzimidazole derivatives for modulating IkB kinase | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2014-07-15 | — | — | US | disclosed |
| EP-2233483-B1 | Indole or Benzimidazole derivatives as IkB-kinase modulators and intermediates in their preparation. | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-05-09 | — | — | EP | disclosed |
| EP-2233483-B1 | Indole or Benzimidazole derivatives as IkB-kinase modulators and intermediates in their preparation. | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-05-09 | — | — | EP | disclosed |
| EP-1530568-B1 | INDOLE OR BENZIMIDAZOLE DERIVATIVES FOR MODULATING I&kB KINASE | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-12-29 | — | — | EP | disclosed |
| EP-1530568-B1 | INDOLE OR BENZIMIDAZOLE DERIVATIVES FOR MODULATING I&kB KINASE | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-12-29 | — | — | EP | disclosed |
| EP-2233483-A1 | Indole or Benzimidazole derivatives as IkB-kinase modulators and intermediates in their preparation. | Sanofi-Aventis Deutschland GmbH (DE) | 2010-09-29 | — | — | EP | disclosed |
| EP-2233483-A1 | Indole or Benzimidazole derivatives as IkB-kinase modulators and intermediates in their preparation. | Sanofi-Aventis Deutschland GmbH (DE) | 2010-09-29 | — | — | EP | disclosed |
| US-7285560-B2 | Indole derivatives or benzimidazole derivatives for modulating IκB kinase | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-10-23 | — | — | US | disclosed |
| US-7285560-B2 | Indole derivatives or benzimidazole derivatives for modulating IκB kinase | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-10-23 | — | — | US | disclosed |
| US-7285560-B2 | Indole derivatives or benzimidazole derivatives for modulating IκB kinase | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-10-23 | — | — | US | disclosed |
| US-20070244139-A1 | Indole Derivatives or Benzimidazole Derivatives for Modulating IkB Kinase | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-10-18 | — | — | US | disclosed |
| US-20070244139-A1 | Indole Derivatives or Benzimidazole Derivatives for Modulating IkB Kinase | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-10-18 | — | — | US | disclosed |
| US-20070244139-A1 | Indole Derivatives or Benzimidazole Derivatives for Modulating IkB Kinase | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-10-18 | — | — | US | disclosed |
| CN-1314683-C | Indole derivatives or benzimidazole derivatives for modulating IKB kinase | AVENTIS PHARMA GMBH (DE) | 2007-05-09 | — | — | CN | disclosed |
| CN-1675196-A | Indole derivatives or benzimidazole derivatives for modulating IKB kinase | AVENTIS PHARMA GMBH (DE) | 2005-09-28 | — | — | CN | disclosed |
| US-20050197353-A1 | Indole derivatives or benzimidazole derivatives for modulating IkB kinase | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244139-A1 | Indole Derivatives or Benzimidazole Derivatives for Modulating IkB Kinase | IKBKB, IKBKG, IKBKE | AURKA 301/4885HDAC3 207/4885HDAC1 432/4885 |
| US-20050197353-A1 | Indole derivatives or benzimidazole derivatives for modulating IkB kinase | IKBKB, IKBKG, IKBKE | AURKA 301/4885HDAC3 207/4885HDAC1 432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.