SCHEMBL27027445

SCHEMBL27027445

CC(C)c1ccc(C(=O)N[C@H]2CC[C@H](N(C)c3ccc(C#N)c(C(F)(F)F)c3)CC2)cn1

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ AR P10275 5/20 0.49
▸ HPGDS O60760 2/20 0.43
▸ PGR P06401 1/20 0.41
▸ TAS1R3 Q7RTX0 1/20 0.39
▸ TAS1R1 Q7RTX1 1/20 0.39
▸ TAS1R2 Q8TE23 1/20 0.39
▸ S1PR1 P21453 1/20 0.38
▸ MAPK14 Q16539 6/20 0.38
▸ CYP2C9 P11712 5/20 0.38
▸ PTK2 Q05397 5/20 0.38
▸ MAPK11 Q15759 2/20 0.37
▸ MAPK13 O15264 1/20 0.37
▸ MAPK12 P53778 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24031259 0.88 AR (0.63) ARHPGDSS1PR1
SCHEMBL27027444 0.85 AR (0.44) ARHPGDSPGRS1PR1
SCHEMBL29316555 0.85 AR (0.57) ARPGRTAS1R3TAS1R1TAS1R2
SCHEMBL29316564 0.84 AR (0.56) ARPGRTAS1R3TAS1R1TAS1R2
SCHEMBL27027437 0.83 AR (0.47) ARHPGDSPGRPTK2
SCHEMBL29316534 0.81 AR (0.53) ARPGRTAS1R3TAS1R1TAS1R2
SCHEMBL29316588 0.78 AR (0.66) AR
SCHEMBL24031263 0.77 AR (0.62) ARHPGDSPGRS1PR1CYP2C9
SCHEMBL29316526 0.77 AR (0.49) ARPGRS1PR1
SCHEMBL26801770 0.76 AR (0.66) ARMAPK14CYP2C9MAPK11MAPK13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240018149-A1 PROTEIN DEGRADATION COMPOUNDS AND METHODS OF USE ANHORN MEDICINES CO., LTD. (TW) 2024-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240018149-A1 PROTEIN DEGRADATION COMPOUNDS AND METHODS OF USE MDM2, PSMG3, ADRM1 AR 2577/4885HPGDS 2667/4885PGR 3489/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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