Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 5/20 | 0.39 |
| ▸ | RXRA | P19793 | 4/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29616596 | 1.00 | NR1H2 (0.39) | NR1H2RXRANR1H3L3MBTL1GAA | |
| SCHEMBL30917881 | 1.00 | NR1H2 (0.39) | NR1H2RXRANR1H3L3MBTL1GAA | |
| SCHEMBL27034709 | 0.92 | NR1H2 (0.37) | NR1H2RXRANR1H3L3MBTL1GAA | |
| SCHEMBL24446810 | 0.89 | IMPDH2 (0.40) | NR1H2RXRANR1H3L3MBTL1GAA | |
| SCHEMBL31036479 | 0.88 | NR1H2 (0.39) | NR1H2RXRANR1H3KMT2ACYP1A2 | |
| SCHEMBL24451644 | 0.88 | IP6K1 (0.40) | NR1H2RXRANR1H3MEN1ALDH1A1 | |
| SCHEMBL24454023 | 0.88 | IP6K1 (0.40) | NR1H2RXRANR1H3MEN1ALDH1A1 | |
| SCHEMBL24403239 | 0.86 | NR1H2 (0.48) | NR1H2RXRANR1H3 | |
| SCHEMBL30599282 | 0.86 | NR1H2 (0.48) | NR1H2RXRANR1H3 | |
| SCHEMBL24403238 | 0.86 | NR1H2 (0.48) | NR1H2RXRANR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118986968-A | Pharmaceutical composition of 3CL inhibitor compound and application thereof | 深圳信立泰药业股份有限公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-118146228-A | Deuterated spiro compound crystal form and preparation method and application thereof | 深圳信立泰药业股份有限公司 | 2024-06-07 | — | — | CN | disclosed |
| WO-2024017270-A1 | SPIRO COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 深圳信立泰药业股份有限公司 | 2024-01-25 | — | — | WO | disclosed |
| CN-116621918-B | Spiro compound and preparation method and application thereof | 深圳信立泰药业股份有限公司 | 2023-10-31 | — | — | CN | disclosed |
| CN-116621918-A | Spiro compound and preparation method and application thereof | 深圳信立泰药业股份有限公司 | 2023-08-22 | — | — | CN | disclosed |