Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 3/20 | 0.52 |
| ▸ | YAP1 | P46937 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 3/20 | 0.38 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27035557 | 0.91 | TEAD1 (0.55) | TEAD1YAP1KIF11EGFRFGFR1 | |
| SCHEMBL27035550 | 0.80 | KIF11 (0.44) | KIF11PTK6AKR1C3AKR1C2BUB1 | |
| SCHEMBL30683315 | 0.80 | KIF11 (0.44) | KIF11PTK6AKR1C3AKR1C2BUB1 | |
| SCHEMBL27035687 | 0.77 | TEAD1 (0.37) | TEAD1YAP1KIF11AKR1C3AKR1C2 | |
| SCHEMBL30683313 | 0.77 | TEAD1 (0.37) | TEAD1YAP1KIF11AKR1C3AKR1C2 | |
| SCHEMBL27035651 | 0.76 | JAK1 (0.42) | TEAD1YAP1KIF11JAK2JAK1 | |
| SCHEMBL31374685 | 0.76 | JAK1 (0.42) | TEAD1YAP1KIF11JAK2JAK1 | |
| SCHEMBL27066709 | 0.75 | PTGER3 (0.35) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL27035555 | 0.75 | TEAD1 (0.58) | TEAD1YAP1KIF11EGFRFGFR1 | |
| SCHEMBL27035701 | 0.73 | TEAD1 (0.58) | TEAD1YAP1EGFRAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4558485-A1 | TEAD INHIBITORS AND METHODS OF USE | Sporos Biodiscovery, Inc. (US) | 2025-05-28 | — | — | EP | disclosed |
| CN-119497708-A | TEAD inhibitors and methods of use | 思博睿生物探索公司 | 2025-02-21 | — | — | CN | disclosed |
| WO-2024020350-A1 | TEAD INHIBITORS AND METHODS OF USE | SPOROS BIODISCOVERY, INC. (US) | 2024-01-25 | — | — | WO | disclosed |