Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2375898 | 0.85 | ALDH1A1 (0.43) | ALDH1A1MEN1TSHRKMT2AATM | |
| SCHEMBL276976 | 0.85 | MCL1 (0.46) | ALDH1A1MEN1TSHRKMT2AATM | |
| SCHEMBL271654 | 0.85 | ALDH1A1 (0.43) | ALDH1A1MEN1TSHRKMT2AATM | |
| SCHEMBL2375905 | 0.85 | KDM4E (0.45) | ALDH1A1MEN1TSHRKMT2AATM | |
| SCHEMBL271995 | 0.83 | MCL1 (0.44) | ALDH1A1MEN1TSHRKMT2AATM | |
| SCHEMBL271989 | 0.83 | CES2 (0.43) | ALDH1A1MEN1TSHRKMT2AATM | |
| SCHEMBL4834548 | 0.83 | IDO1 (0.50) | KMT2AL3MBTL1MCL1FLT1FLT4 | |
| SCHEMBL271970 | 0.81 | CYP19A1 (0.38) | ALDH1A1MEN1TSHRKMT2AATM | |
| SCHEMBL13846826 | 0.81 | KDM4E (0.45) | ALDH1A1MEN1TSHRKMT2AATM | |
| SCHEMBL14426968 | 0.80 | CYP3A4 (0.41) | ALDH1A1MEN1TSHRKMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220056-B1 | HERBICIDAL COMPOUNDS | SYNGENTA LTD (GB) | 2015-09-30 | — | — | EP | disclosed |
| EP-2220056-B1 | HERBICIDAL COMPOUNDS | SYNGENTA LTD (GB) | 2015-09-30 | — | — | EP | disclosed |
| US-8133849-B2 | Herbicidal compounds | SYNGENTA LIMITED (GB) | 2012-03-13 | — | — | US | disclosed |
| US-8133849-B2 | Herbicidal compounds | SYNGENTA LIMITED (GB) | 2012-03-13 | — | — | US | disclosed |
| US-8133849-B2 | Herbicidal compounds | SYNGENTA LIMITED (GB) | 2012-03-13 | — | — | US | disclosed |
| US-20100323889-A1 | HERBICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-12-23 | — | — | US | disclosed |
| US-20100323889-A1 | HERBICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-12-23 | — | — | US | disclosed |
| US-20100323889-A1 | HERBICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-12-23 | — | — | US | disclosed |
| CN-101910138-A | Herbicidal compounds | SYNGENTA LTD | 2010-12-08 | — | — | CN | disclosed |
| EP-2220056-A1 | HERBICIDAL COMPOUNDS | Syngenta Limited (GB) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009063180-A1 | HERBICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2009-05-22 | — | — | WO | disclosed |
| WO-2009063180-A1 | HERBICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2009-05-22 | — | — | WO | disclosed |
| US-20080287466-A1 | 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | ADAMS JERRY LEROY | 2008-11-20 | — | — | US | disclosed |
| US-7427623-B2 | 4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof | SMITHKLINE BEECHAM CORPORATION (US) | 2008-09-23 | — | — | US | disclosed |
| US-20050004142-A1 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2005-01-06 | — | — | US | disclosed |
| EP-1425284-A2 | FURO- AND THIENOPYRIMIDINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003022852-A2 | FURO-AND THIENOPYRIMIDINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004142-A1 | Chemical compounds | TIE1, KDR, TEK | ALDH1A1 906/4885MEN1 303/4885TSHR 3073/4885 |
| US-20100323889-A1 | HERBICIDAL COMPOUNDS | CBR3, DDT, CBR1 | ALDH1A1 127/4885MEN1 2256/4885TSHR 1296/4885 |
| US-20080287466-A1 | 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | TIE1, TEK, KDR | ALDH1A1 1144/4885MEN1 1454/4885TSHR 3243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.