Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.39 |
| ▸ | FPR3 | P25089 | 5/20 | 0.39 |
| ▸ | FPR2 | P25090 | 5/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PTPRB | P23467 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255674 | 0.80 | NPC1 (0.48) | NPC1RECQLRAB9ASMN1; SMN2CTSS | |
| SCHEMBL4380188 | 0.78 | CTSS (0.46) | SMN1; SMN2CTSSCTSKLMNAALDH1A1 | |
| SCHEMBL2436818 | 0.77 | CTSS (0.50) | NPC1RECQLRAB9ASMN1; SMN2CTSS | |
| SCHEMBL20338607 | 0.77 | CTSS (0.50) | NPC1RECQLRAB9ASMN1; SMN2CTSS | |
| SCHEMBL3797749 | 0.76 | NPC1 (0.49) | NPC1RECQLRAB9ASMN1; SMN2CTSS | |
| SCHEMBL5258641 | 0.76 | NPC1 (0.49) | NPC1RECQLRAB9ASMN1; SMN2CTSS | |
| SCHEMBL3670192 | 0.76 | NPC1 (0.49) | NPC1RECQLRAB9ASMN1; SMN2CTSS | |
| SCHEMBL1141998 | 0.72 | NPC1 (0.51) | NPC1RECQLRAB9ASMN1; SMN2CTSS | |
| SCHEMBL28603553 | 0.71 | SMN1; SMN2 (0.39) | NPC1RECQLRAB9ASMN1; SMN2CTSS | |
| SCHEMBL81094 | 0.71 | FPR3 (0.58) | NPC1RECQLRAB9ASMN1; SMN2CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435402-A2 | SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS | Novartis AG (CH) | 2012-04-04 | — | — | EP | disclosed |
| WO-2010136474-A2 | SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS | NOVARTIS AG (CH) | 2010-12-02 | — | — | WO | disclosed |