Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKACG | P22612 | 1/20 | 0.41 |
| ▸ | PRKACB | P22694 | 1/20 | 0.41 |
| ▸ | PRKCH | P24723 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28345274 | 0.78 | ROCK1 (0.52) | LMNAROCK1GLAHSD17B10CYP17A1 | |
| SCHEMBL35210773 | 0.78 | KDM4E (0.51) | LMNAGLAHSD17B10MAPTKDM4E | |
| SCHEMBL28256561 | 0.78 | CDC7 (0.52) | LMNACDC7CDK2ROCK1GLA | |
| SCHEMBL28258022 | 0.74 | HSD17B10 (0.44) | LMNAGLAHSD17B10PDE10ACYP17A1 | |
| SCHEMBL28257961 | 0.74 | LMNA (0.43) | LMNAGLAHSD17B10CYP17A1CYP1A2 | |
| SCHEMBL28257980 | 0.74 | ROCK1 (0.55) | ROCK1PDE10AMAPTPTK2 | |
| SCHEMBL28256466 | 0.74 | CDC7 (0.55) | LMNACDC7CDK2GLAPRKACA | |
| SCHEMBL31525359 | 0.73 | AKR1C3 (0.52) | LMNAROCK1GLAALDH1A1MAPK10 | |
| SCHEMBL28345895 | 0.72 | ALDH1A1 (0.46) | CDC7CDK2ROCK1BIRC5HSD17B10 | |
| SCHEMBL1387982 | 0.72 | PDE10A (0.54) | LMNAROCK1GLAPDE10ACYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110862385-B | Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite | 苏州大学 | 2020-12-08 | — | — | CN | claimed |
| CN-110862385-A | Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite | 苏州大学 | 2020-03-06 | — | — | CN | claimed |
| CN-108774248-B | Method for preparing thiazoloquinazolinone derivative | 苏州大学 | 2020-01-14 | — | — | CN | claimed |
| CN-110862385-B | Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite | 苏州大学 | 2020-12-08 | — | — | CN | disclosed |
| CN-110862385-B | Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite | 苏州大学 | 2020-12-08 | — | — | CN | disclosed |
| CN-110862385-B | Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite | 苏州大学 | 2020-12-08 | — | — | CN | disclosed |
| CN-110862385-A | Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite | 苏州大学 | 2020-03-06 | — | — | CN | disclosed |
| CN-110862385-A | Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite | 苏州大学 | 2020-03-06 | — | — | CN | disclosed |
| CN-110862385-A | Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite | 苏州大学 | 2020-03-06 | — | — | CN | disclosed |
| CN-108774248-B | Method for preparing thiazoloquinazolinone derivative | 苏州大学 | 2020-01-14 | — | — | CN | disclosed |
| CN-108774248-B | Method for preparing thiazoloquinazolinone derivative | 苏州大学 | 2020-01-14 | — | — | CN | disclosed |
| US-7235572-B2 | Thiazolyl-indole derivatives, their manufacture and use as pharmaceutical agents | HOFFMAN-LA ROCHE INC. (US) | 2007-06-26 | — | — | US | disclosed |
| CN-1312154-C | Purine derivatives as kinase inhibitors | LILLY CO ELI (US) | 2007-04-25 | — | — | CN | disclosed |
| US-6998492-B2 | Organometallic complex and light-emitting element containing the same | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2006-02-14 | — | — | US | disclosed |
| CN-1639165-A | Purine derivatives as kinase inhibitors | LILLY CO ELI (US) | 2005-07-13 | — | — | CN | disclosed |
| CN-1609101-A | Organometallic complex and light-emitting element containing the same | SEMICONDUCTOR ENERGY LAB (JP) | 2005-04-27 | — | — | CN | disclosed |
| US-20050033054-A1 | Organometallic complex and light-emitting element containing the same | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. | 2005-02-10 | — | — | US | disclosed |
| US-20050004187-A1 | Thiazolyl-indole derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. | 2005-01-06 | — | — | US | disclosed |
| US-20050004187-A1 | Thiazolyl-indole derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. | 2005-01-06 | — | — | US | disclosed |
| US-20040230061-A1 | Organometallic complex and light-emitting element containing the same | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050033054-A1 | Organometallic complex and light-emitting element containing the same | BCKDK, CCNK, CDK20 | LMNA 2107/4885CDC7 239/4885CDK2 34/4885 |
| US-20050004187-A1 | Thiazolyl-indole derivatives, their manufacture and use as pharmaceutical agents | PPARD, PPARA, PPARG | LMNA 3202/4885CDC7 4471/4885CDK2 1557/4885 |
| US-20040230061-A1 | Organometallic complex and light-emitting element containing the same | NR0B1, BCKDK, NR4A1 | LMNA 2250/4885CDC7 521/4885CDK2 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.