⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2705752 | 1.00 | — | — | |
| SCHEMBL28056778 | 1.00 | — | — | |
| SCHEMBL490278 | 0.87 | — | — | |
| SCHEMBL2580147 | 0.82 | APLNR (0.48) | — | |
| SCHEMBL25948776 | 0.75 | — | — | |
| SCHEMBL7804757 | 0.75 | — | — | |
| SCHEMBL25873238 | 0.75 | — | — | |
| SCHEMBL5035971 | 0.75 | — | — | |
| SCHEMBL2706479 | 0.75 | APLNR (0.32) | — | |
| SCHEMBL27995425 | 0.73 | APLNR (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025224168-A1 | ARYL SULFONE AND SULFANONE DERIVATIVES AS OREXIN RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2025-10-30 | — | — | WO | disclosed |
| WO-2024107438-A1 | BIS-SULFONAMIDE SHIP1 ACTIVATORS | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2024-05-23 | — | — | WO | disclosed |
| EP-3218007-B1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CANCER | INST NAT SANTE RECH MED (FR) | 2022-04-06 | — | — | EP | disclosed |
| US-10975059-B2 | Small molecule BRD4 modulators for HIV epigenetic regulation | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-04-13 | — | — | US | disclosed |
| EP-2608787-B1 | PROLINE SULFONAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-11-20 | — | — | EP | disclosed |
| US-20190292168-A1 | NOVEL SMALL MOLECULE BRD4 MODULATORS FOR HIV EPIGENETIC REGULATION | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-09-26 | — | — | US | disclosed |
| CN-107857719-A | The preparation method of polymer microballoon support L proline sulfonamide | 陕西启源科技发展有限责任公司 | 2018-03-30 | — | — | CN | disclosed |
| CN-107857719-A | The preparation method of polymer microballoon support L proline sulfonamide | 陕西启源科技发展有限责任公司 | 2018-03-30 | — | — | CN | disclosed |
| US-9211279-B2 | Proline sulfonamide derivatives as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2015-12-15 | — | — | US | disclosed |
| US-20150246021-A1 | PROLINE SULFONAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | IDORSIA PHARMACEUTICALS LTD (CH) | 2015-09-03 | — | — | US | disclosed |
| US-20040019019-A1 | Pyrrolo[1,2-b][1,2,4]oxadiazine diones useful as nitric oxide synthase inhibitors | PHARMACIA CORPORATION | 2004-01-29 | — | — | US | disclosed |
| EP-1118907-B1 | Photographic element containing nitrogen heterocycle substituted cyan coupler, compound and process | EASTMAN KODAK CO (US) | 2003-11-19 | — | — | EP | disclosed |
| US-6552052-B2 | (2S,3Z)-2-amino-5-(6,7,8,9-tetrahydro-3-oxo-3H,5H -(1,2,4)oxadiazolo(4,3-a)azepin-5-yl)-3-pentenoic acid, for example | MONSANTO/G.D. SEARLE | 2003-04-22 | — | — | US | disclosed |
| US-6489323-B1 | INHIBITING NO PRODUCTION FROM L-ARGININE, AS SEEN IN DISEASE STATES SUCH AS ARTHRITIS AND SYSTEMIC HYPOTENSION ASSOCIATED WITH SEPTIC AND/OR TOXIC SHOCK | G.D. SEARLE & CO. | 2002-12-03 | — | — | US | disclosed |
| US-20010044539-A1 | Heterobicyclic and tricyclic nitric oxide synthase inhibitors | HANSEN DONALD W (US) | 2001-11-22 | — | — | US | disclosed |
| CN-1308251-A | Photographic element, compound and method containing azacyclo-substrated color former | EASTMAN KODAK CO (US) | 2001-08-15 | — | — | CN | disclosed |
| EP-1118907-A2 | Photographic element containing nitrogen heterocycle substituted cyan coupler, compound and process | EASTMAN KODAK COMPANY (US) | 2001-07-25 | — | — | EP | disclosed |
| EP-1086108-A1 | HETEROBICYCLIC AND TRICYCLIC NITRIC OXIDE SYNTHASE INHIBITORS | G.D. Searle & Co. (US) | 2001-03-28 | — | — | EP | disclosed |
| US-6190852-B1 | COUPLER PROVIDES A DESIRABLY NARROW SPECTROGRAPHIC ABSORPTION CURVE. | EASTMAN KODAK COMPANY | 2001-02-20 | — | — | US | disclosed |
| WO-1999064426-A1 | HETEROBICYCLIC AND TRICYCLIC NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1999-12-16 | — | — | WO | disclosed |