Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717877 | 0.93 | ALDH1A1 (0.40) | HCN4CYP3A4CYP2C19MAPTALDH1A1 | |
| SCHEMBL6816871 | 0.85 | NPSR1 (0.44) | NPSR1CYP3A4MAPTALDH1A1OPRL1 | |
| SCHEMBL16757411 | 0.83 | NPSR1 (0.42) | NPSR1CYP3A4MAPTALDH1A1OPRL1 | |
| SCHEMBL6816556 | 0.83 | NPSR1 (0.41) | NPSR1CYP3A4MAPTALDH1A1OPRL1 | |
| SCHEMBL31527166 | 0.81 | NPSR1 (0.39) | NPSR1CYP3A4CYP2C19ALDH1A1OPRL1 | |
| SCHEMBL14857717 | 0.80 | TSHR (0.47) | NPSR1CYP3A4CYP2C19MAPTALDH1A1 | |
| SCHEMBL31531562 | 0.79 | OPRL1 (0.39) | NPSR1CYP3A4CYP2C19MAPTALDH1A1 | |
| SCHEMBL14597532 | 0.78 | SMN1; SMN2 (0.41) | HCN4MAPTALDH1A1THRBSMN1; SMN2 | |
| SCHEMBL31563786 | 0.78 | USP2 (0.59) | PKMSMN1; SMN2RECQL | |
| SCHEMBL232028 | 0.77 | NPSR1 (0.39) | NPSR1CYP3A4CYP2C19MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435432-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbott Laboratories (US) | 2012-04-04 | — | — | EP | disclosed |
| WO-2010138588-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |