Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2707689 | 0.93 | HCN4 (0.40) | ALDH1A1GLARECQLSMN1; SMN2HCN4 | |
| SCHEMBL31563786 | 0.81 | USP2 (0.59) | RECQLSMN1; SMN2ALOX15PKMTSHR | |
| SCHEMBL32676316 | 0.80 | TSHR (0.51) | ALDH1A1RECQLSMN1; SMN2HPGDALOX15 | |
| SCHEMBL232028 | 0.80 | NPSR1 (0.39) | ALDH1A1CYP3A4CYP2C19HTTMAPT | |
| SCHEMBL15116520 | 0.78 | SMN1; SMN2 (0.45) | ALDH1A1SMN1; SMN2HSD17B10PKMHTT | |
| SCHEMBL6816556 | 0.78 | NPSR1 (0.41) | ALDH1A1CYP3A4CYP2C9MAPT | |
| SCHEMBL25435107 | 0.77 | NPSR1 (0.33) | CYP2C9 | |
| SCHEMBL21877094 | 0.77 | KMT2A (0.34) | HCN4 | |
| SCHEMBL29023210 | 0.77 | SMN1; SMN2 (0.37) | ALDH1A1GLARECQLSMN1; SMN2HCN4 | |
| SCHEMBL29239683 | 0.76 | OPRL1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136778-A1 | DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010136778-A1 | DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |