Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | SDCBP | O00560 | 1/20 | 0.33 |
| ▸ | SDC2 | P34741 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.33 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27080877 | 1.00 | PRMT5 (0.35) | PRMT5WDR77KDM4EALOX15TSHR | |
| SCHEMBL29984097 | 0.87 | PRMT5 (0.32) | PRMT5WDR77CRBNDDB1SDCBP | |
| SCHEMBL27081925 | 0.87 | PRMT5 (0.32) | PRMT5WDR77CRBNDDB1SDCBP | |
| SCHEMBL27080713 | 0.82 | ROCK1 (0.33) | PRMT5WDR77CRBNCSNK1A1 | |
| SCHEMBL27080095 | 0.82 | ROCK1 (0.33) | PRMT5WDR77CRBNCSNK1A1 | |
| SCHEMBL23725965 | 0.81 | CD274 (0.36) | KCNA5 | |
| SCHEMBL27080414 | 0.81 | CD274 (0.36) | KCNA5 | |
| SCHEMBL27080699 | 0.77 | CD274 (0.37) | PRMT5WDR77CRBNDDB1 | |
| SCHEMBL27080704 | 0.77 | CD274 (0.37) | PRMT5WDR77CRBNDDB1 | |
| SCHEMBL27080770 | 0.76 | PRF1 (0.34) | PRMT5WDR77CRBNDDB1SDCBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313968-A2 | SUBSTITUTED 1-ARYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1,1'-BIHETEROARYL COMPOUNDS, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2024-02-07 | — | — | EP | disclosed |