Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | PARG | Q86W56 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27080095 | 1.00 | ROCK1 (0.33) | ROCK1PRMT5WDR77CSNK1A1CRBN | |
| SCHEMBL29983196 | 0.89 | PRMT5 (0.35) | ROCK1PRMT5WDR77BACE1 | |
| SCHEMBL27080703 | 0.82 | PRMT5 (0.35) | PRMT5WDR77CSNK1A1CRBN | |
| SCHEMBL27080877 | 0.82 | PRMT5 (0.35) | PRMT5WDR77CSNK1A1CRBN | |
| SCHEMBL15796134 | 0.76 | PIK3CA (0.41) | ROCK1PRMT5WDR77BACE1 | |
| SCHEMBL23725965 | 0.75 | CD274 (0.36) | — | |
| SCHEMBL27080414 | 0.75 | CD274 (0.36) | — | |
| SCHEMBL27036633 | 0.74 | CD274 (0.36) | ROCK1BACE1 | |
| SCHEMBL27131394 | 0.74 | CD274 (0.36) | ROCK1BACE1 | |
| SCHEMBL22408571 | 0.73 | PRF1 (0.43) | ROCK1PRMT5WDR77BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313968-A2 | SUBSTITUTED 1-ARYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1,1'-BIHETEROARYL COMPOUNDS, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2024-02-07 | — | — | EP | disclosed |