Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LDHA | P00338 | 1/20 | 0.30 |
| ▸ | LDHB | P07195 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27082164 | 0.92 | CHRM1 (0.33) | CHRM1SLC6A2SLC6A4SLC6A3HCAR3 | |
| SCHEMBL27083197 | 0.72 | KCNA3 (0.32) | CHRM1KCNA3 | |
| SCHEMBL27082374 | 0.71 | KCNA3 (0.36) | CHRM1SLC6A2SLC6A4SLC6A3KCNA3 | |
| SCHEMBL11321747 | 0.69 | SLC6A2 (0.33) | SLC6A2SLC6A4 | |
| SCHEMBL568885 | 0.69 | MEN1 (0.41) | — | |
| SCHEMBL4444902 | 0.68 | CHRM1 (0.33) | CHRM1SLC6A2SLC6A4SLC6A3HCAR3 | |
| SCHEMBL19866165 | 0.67 | ESR1 (0.43) | CHRM1SLC6A2SLC6A4HCAR3HCAR2 | |
| SCHEMBL28018276 | 0.67 | CES2 (0.40) | CHRM1SLC6A2SLC6A4SLC6A3HCAR3 | |
| SCHEMBL27082151 | 0.65 | — | — | |
| SCHEMBL8290260 | 0.65 | CYP2A6 (0.41) | SLC6A2SLC6A4SLC6A3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240190888-A1 | SPIRO-CONTAINING DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | SHUJING BIOPHARMA CO., LTD (CN) | 2024-06-13 | — | — | US | disclosed |
| EP-4317164-A1 | SPIRO-CONTAINING DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shujing Biopharma Co., Ltd (CN) | 2024-02-07 | — | — | EP | disclosed |
| CN-116987095-A | Spiro-containing derivative, preparation method and application thereof | 上海枢境生物科技有限公司 | 2023-11-03 | — | — | CN | disclosed |
| CN-116057060-B | Spiro-containing derivative, preparation method and application thereof | 上海枢境生物科技有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-116057060-A | Spiro-containing derivative, preparation method and application thereof | 上海枢境生物科技有限公司 | 2023-05-02 | — | — | CN | disclosed |
| WO-2022206706-A1 | SPIRO-CONTAINING DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海枢境生物科技有限公司 | 2022-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240190888-A1 | SPIRO-CONTAINING DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | TACR1, HTR5A, TACR2 | CHRM1 1558/4885SLC6A2 42/4885SLC6A4 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.