Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | BCR | P11274 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19121067 | 0.84 | SCN5A (0.47) | MAPTMAPK1KDM4EGAARECQL | |
| SCHEMBL2708649 | 0.83 | RAB9A (0.48) | MAPTKDM4EADORA2A | |
| SCHEMBL182081 | 0.82 | MRGPRX4 (0.49) | ABL1BCRMAPTMAPK1KDM4E | |
| SCHEMBL182036 | 0.82 | GRM5 (0.53) | ABL1MAPTMAPK1KDM4EGAA | |
| SCHEMBL17125341 | 0.81 | DYRK1A (0.45) | ABL1BCRMAPTMAPK1KDM4E | |
| SCHEMBL2708555 | 0.80 | ALDH1A1 (0.50) | MAPTKDM4EL3MBTL1 | |
| SCHEMBL2707485 | 0.75 | ALDH1A1 (0.50) | MAPTMAPK1KDM4EADORA2A | |
| SCHEMBL19121178 | 0.75 | MAPT (0.42) | MAPTMAPK1KDM4EGAARECQL | |
| SCHEMBL1241524 | 0.75 | ABL1 (0.54) | ABL1BCRMAPK1SCN5A | |
| SCHEMBL30363971 | 0.75 | ABL1 (0.54) | ABL1BCRMAPK1SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387995-A1 | Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith | PTC Therapeutics, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |
| WO-2007117438-A2 | METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCIATED THEREWITH | PTC THERAPEUTICS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |