Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2708649 | 0.89 | RAB9A (0.48) | ALDH1A1CYP3A4MAPK10ADORA2AADORA1 | |
| SCHEMBL2708555 | 0.83 | ALDH1A1 (0.50) | ALDH1A1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL182440 | 0.81 | GRM5 (0.56) | ALDH1A1CYP3A4MAPK10ADORA2AADORA1 | |
| SCHEMBL182362 | 0.81 | STIM1 (0.57) | ALDH1A1MAPK10NPC1RAB9APOLB | |
| SCHEMBL181964 | 0.79 | STIM1 (0.58) | ALDH1A1ADORA2AADORA1ADORA3POLB | |
| SCHEMBL27636269 | 0.78 | NOTUM (0.55) | ALDH1A1CYP3A4ADORA2AADORA1ADORA3 | |
| SCHEMBL2710669 | 0.76 | KEAP1 (0.46) | ALDH1A1KEAP1NFE2L2MEN1NPC1 | |
| SCHEMBL2708402 | 0.75 | ABL1 (0.51) | ADORA2AKDM4EMAPTMAPK1 | |
| SCHEMBL182223 | 0.75 | CYP2C8 (0.51) | ALDH1A1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL181763 | 0.74 | STIM1 (0.59) | POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387995-A1 | Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith | PTC Therapeutics, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |
| WO-2007117438-A2 | METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCIATED THEREWITH | PTC THERAPEUTICS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |