Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31458870 | 0.87 | CDK5 (0.49) | PIM1ROCK1CLK4CSNK1A1CDK5 | |
| SCHEMBL22981764 | 0.84 | PARP10 (0.51) | PARP10PARP11 | |
| SCHEMBL29698267 | 0.84 | PARP10 (0.51) | PARP10PARP11 | |
| SCHEMBL27085852 | 0.81 | GRM2 (0.44) | PIM1ROCK1CLK4CSNK1A1CDK5 | |
| SCHEMBL32686624 | 0.80 | CLK1 (0.38) | PIM1ROCK1CLK4CSNK1A1CDK5 | |
| SCHEMBL1334392 | 0.77 | CLK4 (0.53) | PIM1ROCK1CLK4CSNK1A1CDK5 | |
| SCHEMBL29841781 | 0.76 | HTR2A (0.38) | PIM1ROCK1CLK4CSNK1A1CDK5 | |
| SCHEMBL29089792 | 0.76 | GRM2 (0.40) | PIM1ROCK1CLK4CSNK1A1CDK5 | |
| SCHEMBL21200175 | 0.76 | HTR2A (0.38) | PIM1ROCK1CLK4CSNK1A1CDK5 | |
| SCHEMBL32686358 | 0.76 | GRM2 (0.35) | PIM1ROCK1CLK4CSNK1A1CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117858707-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| EP-4319756-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022217276-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-10-13 | — | — | WO | disclosed |