Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.52 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LSS | P48449 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29754911 | 1.00 | KMT2A (0.53) | KMT2AHPGDERCC1ERCC4SMN1; SMN2 | |
| SCHEMBL5177358 | 0.86 | KDM4E (0.60) | KMT2AHPGDALDH1A1MAPK1KDM4E | |
| SCHEMBL27090197 | 0.82 | FFAR1 (0.64) | KMT2ASMN1; SMN2FFAR1MEN1ALDH1A1 | |
| SCHEMBL29754989 | 0.82 | FFAR1 (0.64) | KMT2ASMN1; SMN2FFAR1MEN1ALDH1A1 | |
| SCHEMBL5178619 | 0.82 | GAA (0.54) | KMT2AHPGDERCC1ERCC4SMN1; SMN2 | |
| SCHEMBL24590728 | 0.81 | NR4A1 (0.48) | KMT2AFFAR1ALDH1A1HTTKDM4E | |
| SCHEMBL3567670 | 0.81 | KMT2A (0.73) | KMT2AHPGDERCC1ERCC4MEN1 | |
| SCHEMBL12082548 | 0.79 | SYK (0.58) | KMT2AFFAR1HTTKDM4EGAA | |
| SCHEMBL9263657 | 0.78 | KDM4E (0.63) | KMT2AHPGDSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL5272546 | 0.78 | TRPV1 (0.58) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240051975-A1 | NOVEL NAMPT ENZYME AGONIST AND PREPARATION AND USE THEREOF | TSINGHUA UNIVERSITY (CN) | 2024-02-15 | — | — | US | disclosed |
| CN-114716343-B | Novel NAMPT enzyme agonist, preparation and application thereof | 清华大学 | 2023-03-21 | — | — | CN | disclosed |
| CN-114716343-A | Novel NAMPT enzyme agonist, preparation and application thereof | 清华大学 | 2022-07-08 | — | — | CN | disclosed |
| WO-2022135617-A1 | NOVEL NAMPT ENZYME AGONIST AND PREPARATION AND USE THEREOF | 清华大学 | 2022-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240051975-A1 | NOVEL NAMPT ENZYME AGONIST AND PREPARATION AND USE THEREOF | NAMPT, NAT1, SIRT1 | KMT2A 1803/4885HPGD 146/4885ERCC1 4529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.