Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 3/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3811870 | 0.95 | SIGMAR1 (0.53) | SIGMAR1CYP2A6OPRM1OPRK1ALDH1A1 | |
| Oxalic Acid SCHEMBL3807802 | 0.94 | SIGMAR1 (0.51) | SIGMAR1CYP2A6OPRM1OPRK1KDM4E | |
| SCHEMBL3807910 | 0.93 | SIGMAR1 (0.51) | SIGMAR1CYP2A6OPRM1OPRK1ALDH1A1 | |
| Fumaric Acid SCHEMBL6522397 | 0.92 | SIGMAR1 (0.60) | SIGMAR1CYP2A6OPRM1OPRK1LTA4H | |
| Fumaric Acid SCHEMBL6522403 | 0.92 | SIGMAR1 (0.60) | SIGMAR1CYP2A6OPRM1OPRK1LTA4H | |
| SCHEMBL3810177 | 0.91 | SIGMAR1 (0.52) | SIGMAR1CYP2A6OPRM1OPRK1ALDH1A1 | |
| Oxalic Acid SCHEMBL3811633 | 0.90 | SIGMAR1 (0.49) | SIGMAR1CYP2A6OPRM1OPRK1KDM4E | |
| Oxalic Acid SCHEMBL3807582 | 0.87 | SIGMAR1 (0.48) | SIGMAR1CYP2A6OPRM1OPRK1ALDH1A1 | |
| SCHEMBL14492178 | 0.86 | SIGMAR1 (0.53) | SIGMAR1CYP2A6OPRM1OPRK1ALDH1A1 | |
| Oxalic Acid SCHEMBL3808414 | 0.85 | SIGMAR1 (0.48) | SIGMAR1CYP2A6OPRM1OPRK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1514542-B1 | Medicinal composition comprising Tacrine or Donepezil for improving brain function. | TOYAMA CHEMICAL CO LTD (JP) | 2012-02-22 | — | — | EP | claimed |
| EP-2389937-A1 | Medicinal composition for improving brain function | TOYAMA CHEMICAL CO., LTD. (JP) | 2011-11-30 | — | — | EP | claimed |
| US-8038956-B2 | Catalyzed soot filter manufacture and systems | BASF CORPORATION (US) | 2011-10-18 | — | — | US | claimed |
| US-7834053-B2 | Medicinal compositions improving brain function and method for improving brain function | TOYAMA CHEMICAL CO., LTD. (JP) | 2010-11-16 | — | — | US | claimed |
| US-20080103126-A1 | Medicinal compositions improving brain function and method for improving brian function | TOYAMA CHEMICAL CO., LTD. (JP) | 2008-05-01 | — | — | US | claimed |
| EP-1514542-B1 | Medicinal composition comprising Tacrine or Donepezil for improving brain function. | TOYAMA CHEMICAL CO LTD (JP) | 2012-02-22 | — | — | EP | disclosed |
| EP-2389937-A1 | Medicinal composition for improving brain function | TOYAMA CHEMICAL CO., LTD. (JP) | 2011-11-30 | — | — | EP | disclosed |
| US-8038956-B2 | Catalyzed soot filter manufacture and systems | BASF CORPORATION (US) | 2011-10-18 | — | — | US | disclosed |
| US-RE42327-E1 | Medicinal compositions improving brain function and method for improving brain function | TOYAMA CHEMICAL CO., LTD. (JP) | 2011-05-03 | — | — | US | disclosed |
| US-7834053-B2 | Medicinal compositions improving brain function and method for improving brain function | TOYAMA CHEMICAL CO., LTD. (JP) | 2010-11-16 | — | — | US | disclosed |
| EP-1186594-B1 | N-ALKOXYALKYL-N,N-DIALKYLAMINE DERIVATIVES OR SALTS THEREOF, AND REMEDIES FOR NERVE DEGENERATION DISEASES CONTAINING THE SAME | TOYAMA CHEMICAL CO LTD (JP) | 2009-08-05 | — | — | EP | disclosed |
| US-20080103126-A1 | Medicinal compositions improving brain function and method for improving brian function | TOYAMA CHEMICAL CO., LTD. (JP) | 2008-05-01 | — | — | US | disclosed |
| US-7342043-B2 | synergistic antihypoxic mixture: acetylcholine esterase inhibitor (Donepezil and Tacrine) and neuroprotectant 1-[3-(2-(1-benzothiophen-5-yl)ethoxy)propyl]-3-azetidinol maleate; dysfunction of cerebral acetylcholine neurons in sequelae of cerebrovascular and senile dementia, Alzheimer's disease | TOYAMA CHEMICAL CO., LTD. (JP) | 2008-03-11 | — | — | US | disclosed |
| US-20050250843-A1 | Medicinal compositions improving brain function and method for improving brain function | TOYAMA CHEMICAL CO., LTD. (JP) | 2005-11-10 | — | — | US | disclosed |
| EP-1514542-A1 | MEDICINAL COMPOSITIONS IMPROVING BRAIN FUNCTION AND METHOD FOR IMPROVING BRAIN FUNCTION | TOYAMA CHEMICAL CO., LTD. (JP) | 2005-03-16 | — | — | EP | disclosed |
| US-6797726-B1 | N-alkoxyalkyl-N,N-dialkylamine derivatives or salts thereof, and remedies for nerve degeneration diseases containing the same | TOYAMA CHEMICAL CO., LTD. (JP) | 2004-09-28 | — | — | US | disclosed |
| EP-1186594-A1 | N-ALKOXYALKYL-N,N-DIALKYLAMINE DERIVATIVES OR SALTS THEREOF, AND REMEDIES FOR NERVE DEGENERATION DISEASES CONTAINING THE SAME | TOYAMA CHEMICAL CO., LTD. (JP) | 2002-03-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250843-A1 | Medicinal compositions improving brain function and method for improving brain function | CHRM2, ACHE, CHAT | SIGMAR1 1872/4885CYP2A6 1840/4885OPRM1 1553/4885 |
| US-20080103126-A1 | Medicinal compositions improving brain function and method for improving brian function | CHRM2, ACHE, CHRM1 | SIGMAR1 2325/4885CYP2A6 1942/4885OPRM1 1094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.