Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | LSS | P48449 | 3/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 3/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6522403 | 1.00 | SIGMAR1 (0.60) | SIGMAR1OPRM1OPRK1LSSCYP2A6 | |
| Fumaric Acid SCHEMBL3811781 | 0.94 | SIGMAR1 (0.57) | SIGMAR1OPRM1OPRK1LSSCYP2A6 | |
| Fumaric Acid SCHEMBL3811775 | 0.94 | SIGMAR1 (0.57) | SIGMAR1OPRM1OPRK1LSSCYP2A6 | |
| Oxalic Acid SCHEMBL3807802 | 0.93 | SIGMAR1 (0.51) | SIGMAR1OPRM1OPRK1CYP2A6LTA4H | |
| SCHEMBL27091 | 0.92 | SIGMAR1 (0.55) | SIGMAR1OPRM1OPRK1CYP2A6LTA4H | |
| Oxalic Acid SCHEMBL3811633 | 0.89 | SIGMAR1 (0.49) | SIGMAR1OPRM1OPRK1LSSCYP2A6 | |
| SCHEMBL3811870 | 0.87 | SIGMAR1 (0.53) | SIGMAR1OPRM1OPRK1LSSCYP2A6 | |
| Oxalic Acid SCHEMBL3807582 | 0.86 | SIGMAR1 (0.48) | SIGMAR1OPRM1OPRK1CYP2A6MRGPRX4 | |
| SCHEMBL3807910 | 0.85 | SIGMAR1 (0.51) | SIGMAR1OPRM1OPRK1CYP2A6 | |
| Oxalic Acid SCHEMBL3808414 | 0.85 | SIGMAR1 (0.48) | SIGMAR1OPRM1OPRK1CYP2A6LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050250843-A1 | Medicinal compositions improving brain function and method for improving brain function | TOYAMA CHEMICAL CO., LTD. (JP) | 2005-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250843-A1 | Medicinal compositions improving brain function and method for improving brain function | CHRM2, ACHE, CHAT | HRH1 804/4885SIGMAR1 1872/4885OPRM1 1553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.