Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | KLK1 | P06870 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21376960 | 0.79 | PIK3CA (0.50) | PIK3CAOGAABL1HCRTR1HCRTR2 | |
| SCHEMBL13069962 | 0.77 | PIK3CA (0.53) | PIK3CAOGAABL1ALDH1A1HCRTR1 | |
| SCHEMBL8197483 | 0.72 | PIK3CA (0.59) | PIK3CAOGAHCRTR1HCRTR2OPRM1 | |
| SCHEMBL7679073 | 0.68 | CYP3A4 (0.45) | PIK3CAOGAKDM4ENAPEPLDSLC40A1 | |
| SCHEMBL7677919 | 0.67 | CYP2C19 (0.67) | PIK3CAALDH1A1SLC40A1 | |
| SCHEMBL13725415 | 0.67 | LRRK2 (0.50) | PIK3CAOGAABL1OPRM1OPRL1 | |
| SCHEMBL13028832 | 0.67 | PIK3CA (0.50) | PIK3CAOGAABL1HCRTR1HCRTR2 | |
| SCHEMBL10154083 | 0.67 | PIK3CA (0.50) | PIK3CAOGAKDM4EALDH1A1MAPT | |
| SCHEMBL14615359 | 0.67 | HRH3 (0.50) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL15621623 | 0.66 | HRH4 (0.49) | PIK3CAMAPTCASP1AOC3HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076650-B1 | 3-(5-METHOXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF | NOVARTIS AG (CH) | 2024-02-28 | — | — | EP | disclosed |